Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning
| العنوان: | Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning |
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| المؤلفون: | Henk-Jan Boele, Chris I. De Zeeuw, Tom J. H. Ruigrok, Zhanmin Lin, Martina Proietti-Onori, Zhenyu Gao, Michiel M. ten Brinke, Freek E. Hoebeek, Jan-Willem Potters |
| المساهمون: | Netherlands Institute for Neuroscience (NIN), Neurosciences |
| المصدر: | Neuron Neuron, 89(3), 645-57. Cell Press Neuron, 89(3), 645-657. Cell Press |
| بيانات النشر: | Cell Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Associative conditioning, Cerebellum, Neuroscience(all), Conditioning, Classical, Optogenetics, Article, 03 medical and health sciences, Mice, Cerebellar Cortex, 0302 clinical medicine, Nerve Fibers, Interposed nucleus, Neural Pathways, medicine, Animals, Blinking, Chemistry, General Neuroscience, Association Learning, 030104 developmental biology, medicine.anatomical_structure, Eyeblink conditioning, Cerebellar Nuclei, Cerebellar cortex, Excitatory postsynaptic potential, Female, Motor learning, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Summary Closed-loop circuitries between cortical and subcortical regions can facilitate precision of output patterns, but the role of such networks in the cerebellum remains to be elucidated. Here, we characterize the role of internal feedback from the cerebellar nuclei to the cerebellar cortex in classical eyeblink conditioning. We find that excitatory output neurons in the interposed nucleus provide efference-copy signals via mossy fibers to the cerebellar cortical zones that belong to the same module, triggering monosynaptic responses in granule and Golgi cells and indirectly inhibiting Purkinje cells. Upon conditioning, the local density of nucleocortical mossy fiber terminals significantly increases. Optogenetic activation and inhibition of nucleocortical fibers in conditioned animals increases and decreases the amplitude of learned eyeblink responses, respectively. Our data show that the excitatory nucleocortical closed-loop circuitry of the cerebellum relays a corollary discharge of premotor signals and suggests an amplifying role of this circuitry in controlling associative motor learning. Highlights • Cerebellar nuclei provide modular corollary discharge to the cerebellar cortex • Nucleocortical afferents have unique molecular and ultrastructural features • Eyeblink conditioning induces structural plasticity of nucleocortical mossy fibers • Nucleocortical afferents amplify the amplitude of conditioned eyeblink responses The role of the closed-loop circuitry between cerebellar nuclei and cortex is unknown. Gao et al. show that nucleocortical inputs provide corollary discharges to the granular layer, are plastic upon eyeblink conditioning, and amplify the amplitude of conditioned responses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1097-4199 0896-6273 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e200ff337244e3b7ba08fb1eb5342e1b http://europepmc.org/articles/PMC4742536 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e200ff337244e3b7ba08fb1eb5342e1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974199 08966273 |
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