Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock
| العنوان: | Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock |
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| المؤلفون: | Vincent Maréchal, Sébastien Gibot, Srini V. Kaveri, Chloé Borde, Stéphanie Barnay-Verdier, Lakhdar Fattoum |
| المصدر: | Intensive Care Medicine. 37:957-962 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Survival, Enzyme-Linked Immunosorbent Assay, chemical and pharmacologic phenomena, Critical Care and Intensive Care Medicine, medicine.disease_cause, HMGB1, Autoimmunity, Sepsis, Intensive care, Anesthesiology, medicine, Humans, HMGB1 Protein, Aged, Autoantibodies, biology, business.industry, Septic shock, Autoantibody, Middle Aged, medicine.disease, Shock, Septic, Intensive Care Units, Shock (circulatory), Immunology, biology.protein, Female, France, medicine.symptom, business |
| الوصف: | To assess the prevalence and predictive value of natural autoantibodies to high-mobility group box 1 (HMGB1) during sepsis.Anti-HMGB1 and anti-human serum albumin (HSA) autoantibodies were detected by ELISA in 178 plasma samples longitudinally collected from 40 critically ill patients with septic shock. One hundred thirty-two plasma samples from healthy donors were used as control.IgGs to HMGB1 were detected in 15/40 patients (37.5%). The prevalence of anti-HMGB1 antibodies was significantly higher in the patients who survived (55%) compared to the patients who did not (20%) (p0.0001). The detection of anti-HMGB1 antibodies during the course of the disease was significantly associated with patient survival (p=0.038). Moreover, there is a progressive and significant emergence of anti-HMGB1 antibodies during the course of the disease, mostly in patients who survived.This study shows that autoantibodies to HMGB1 are produced during sepsis and are associated with a favorable outcome in patients undergoing septic shock. |
| تدمد: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s00134-011-2192-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1791f2bdc4b2f9e583e810ea97fc582 https://doi.org/10.1007/s00134-011-2192-6 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e1791f2bdc4b2f9e583e810ea97fc582 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321238 03424642 |
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| DOI: | 10.1007/s00134-011-2192-6 |