Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth
| العنوان: | Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth |
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| المؤلفون: | Hiroko Fukushima, Hiromi Hamada, Yu Kanai, Yoshiaki Kato, Ryo Sumazaki, Tomohiro Kamoda, Atsushi Iwabuchi, Emiko Noguchi, Yayoi Miyazono, Tadao Arinami, Kazunori Nishimura, Makoto Saito |
| المصدر: | Journal of Human Genetics. 57:109-114 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Genotype, Adiponectin, business.industry, Infant, Newborn, nutritional and metabolic diseases, ADIPOQ Gene, Fetal Blood, Polymorphism, Single Nucleotide, Fetal Development, Endocrinology, Cord blood, Internal medicine, Genetics, Birth Weight, Humans, Medicine, Female, business, Genetic Association Studies, hormones, hormone substitutes, and hormone antagonists, Genetics (clinical) |
| الوصف: | To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: -0.06±0.75 versus CG: 0.20±0.64 versus GG: 0.07±0.78; P=1.65 × 10(-3), adjusted P=9.90 × 10(-3)). However, this difference was not significant after adjustment for cord blood adiponectin (P=0.04, adjusted P=0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1±20.2 versus CG: 44.3±26.1 versus GG: 54.1±36.7 μg ml(-1), P=2.80 × 10(-9), adjusted P=1.68 × 10(-8)). This association remained after adjustment for birth weight s.d. score (P=6.63 × 10(-8), adjusted P=3.98 × 10(-7)). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin. |
| تدمد: | 1435-232X 1434-5161 1686-1205 |
| DOI: | 10.1038/jhg.2011.134 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13b2a9e4039dd516737f45e503c1736 https://doi.org/10.1038/jhg.2011.134 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e13b2a9e4039dd516737f45e503c1736 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1435232X 14345161 16861205 |
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| DOI: | 10.1038/jhg.2011.134 |