Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice
| العنوان: | Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice |
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| المؤلفون: | Waldiceu A. Verri, Ana C. Rossaneis, Mab Pereira Corrêa, Cássia Calixto-Campos, Ana C. Zarpelon, Letícia Coelho-Silva, Thacyana T. Carvalho, Cátia Campaner Ferrari Bernardy, Wander Rogério Pavanelli, Phileno Pinge-Filho, Rubia Casagrande, Jefferson Crespigio, Miriam S. N. Hohmann |
| المصدر: | Analytical Cellular Pathology, Vol 2015 (2015) Analytical Cellular Pathology (Amsterdam) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_treatment, Interleukin-1beta, Anti-Inflammatory Agents, (+)-Naloxone, Pharmacology, medicine.disease_cause, chemistry.chemical_compound, Mice, Opioid receptor, heterocyclic compounds, RC254-282, Skin, Analgesics, Behavior, Animal, Morphine, Naloxone, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, General Medicine, Analgesics, Opioid, Cytokine, Neutrophil Infiltration, Spinal Cord, Molecular Medicine, Tumor necrosis factor alpha, Drug Therapy, Combination, Female, Quercetin, medicine.drug, Research Article, Article Subject, medicine.drug_class, Analgesic, Pain, Pathology and Forensic Medicine, medicine, Animals, Carcinoma, Ehrlich Tumor, Dose-Response Relationship, Drug, QH573-671, business.industry, Tumor Necrosis Factor-alpha, Cell Biology, Oxidative Stress, chemistry, Immunology, business, Cytology, Oxidative stress |
| الوصف: | Cancer pain directly affects the patient’s quality of life. We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice. Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity. Therefore, the analgesic effect and mechanisms of quercetin were evaluated in Ehrlich tumor-induced cancer pain in mice. Intraperitoneal (i.p.) treatments with quercetin reduced Ehrlich tumor-induced mechanical and thermal hyperalgesia, but not paw thickness or histological alterations, indicating an analgesic effect without affecting tumor growth. Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1βand TNFαand decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress. Naloxone (opioid receptor antagonist) inhibited quercetin analgesia without interfering with neutrophil recruitment, cytokine production, and oxidative stress. Importantly, cotreatment with morphine and quercetin at doses that were ineffective as single treatment reduced the nociceptive responses. Concluding, quercetin reduces the Ehrlich tumor-induced cancer pain by reducing the production of hyperalgesic cytokines, neutrophil recruitment, and oxidative stress as well as by activating an opioid-dependent analgesic pathway and potentiation of morphine analgesia. Thus, quercetin treatment seems a suitable therapeutic approach for cancer pain that merits further investigation. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2210-7185 2210-7177 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b90738bf6aee1776e2d933b03839d https://doaj.org/article/e8a8e1181ed54492b1be801a5d041cff |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e09b90738bf6aee1776e2d933b03839d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22107185 22107177 |
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