Interictal pontine metabolism in migraine without aura patients: A 3 Tesla proton magnetic resonance spectroscopy study
| العنوان: | Interictal pontine metabolism in migraine without aura patients: A 3 Tesla proton magnetic resonance spectroscopy study |
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| المؤلفون: | Messoud Ashina, Henrik Larsson, Olaf B. Paulson, Anders Hougaard, Casper Emil Christensen, Samaira Younis, Mark B Vestergaard |
| المصدر: | NeuroImage: Clinical, Vol 32, Iss, Pp 102824-(2021) Younis, S, Hougaard, A, Christensen, C E, Vestergaard, M B, Paulson, O B, Larsson, H B W & Ashina, M 2021, ' Interictal pontine metabolism in migraine without aura patients : A 3 Tesla proton magnetic resonance spectroscopy study ', NeuroImage: Clinical, vol. 32, 102824 . https://doi.org/10.1016/j.nicl.2021.102824 NeuroImage : Clinical |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Migraine without Aura, Glx, glutamate+glutamine, Aura, CRLB, Cramér–Rao lower bounds, Proton Magnetic Resonance Spectroscopy, 1H-MRS, proton magnetic resonance spectroscopy, Pons, total NAA, N-acetylaspartate + N-acetylaspartylglutamate, FWHM, full-width of half-maximum, Trigeminovascular system, Glutamate receptor, Headache, Regular Article, SNR, signal-to-noise ratio, Magnetic Resonance Imaging, Mitochondrial, Neurology, Brainstem, 31P-MRS, phosphorous magnetic resonance spectroscopy, Glutamate, medicine.medical_specialty, 1H-MRS, Cognitive Neuroscience, Computer applications to medicine. Medical informatics, R858-859.7, Glutamic Acid, GABA, gamma-aminobutyric acid, Glutamatergic, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Ictal, H-MRS, RC346-429, IQR, interquartile range, business.industry, Energy metabolism, medicine.disease, Creatine, Endocrinology, Migraine, total creatine, creatine + phosphocreatine, Neurology (clinical), Neurology. Diseases of the nervous system, business, ICHD, International Classification of Headache Disorders, SE, standard error of the mean |
| الوصف: | Highlights • Migraine patients were scanned by a 1H-MRS protocol optimized to target the pons. • Measurements were repeated on two separate days to increase accuracy. • Pontine glutamate levels were not increased outside attacks in patients. • Interestingly, interictal pontine total creatine levels were increased in patients. • Imbalanced pontine energy metabolism may be a potential imaging marker in migraine. In the pons, glutamatergic mechanisms are involved in regulating inhibitory descending pain modulation, serotoninergic neurotransmission as well as modulating the sensory transmission of the trigeminovascular system. Migraine involves altered pontine activation and structural changes, while biochemical, genetic and clinical evidence suggests that altered interictal pontine glutamate levels may be an important pathophysiological feature of migraine abetting to attack initiation. Migraine without aura patients were scanned outside attacks using a proton magnetic resonance spectroscopy protocol optimized for the pons at 3 Tesla. The measurements were performed on two separate days to increase accuracy and compared to similar repeated measurements in healthy controls. We found that interictal glutamate (i.e. Glx) levels in the pons of migraine patients (n = 33) were not different from healthy controls (n = 16) (p = 0.098), while total creatine levels were markedly increased in patients (9%, p = 0.009). There was no correlation of glutamate or total creatine levels to migraine frequency, days since the last attack, usual pain intensity of attacks or disease duration. In conclusion, migraine is not associated with altered interictal pontine glutamate levels. However, the novel finding of increased total creatine levels suggests that disequilibrium in the pontine energy metabolism could be an important feature of migraine pathophysiology. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2021.102824 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd54df546f3816aab59c9ed8ab72d9 http://www.sciencedirect.com/science/article/pii/S2213158221002680 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dfcd54df546f3816aab59c9ed8ab72d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2021.102824 |