Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?
| العنوان: | Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins? |
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| المؤلفون: | Silvana Alfei, Guendalina Zuccari, Barbara Marengo |
| المصدر: | Antioxidants Antioxidants, Vol 9, Iss 707, p 707 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Antioxidant, Physiology, oxidative stress, reactive oxygen and nitrogen species, antioxidant effects, ellagitannins, ellagic acid, urolithins, human metabotype, pro-oxidant effects, EA-enriched food supplements, medicine.medical_treatment, ellagitannins (ETs), Clinical Biochemistry, urolithins (UROs), Review, Pharmacology, pro-oxidant effects, medicine.disease_cause, Biochemistry, antioxidant effects, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, ellagic acid, ellagitannins, medicine, oxidative stress, Molecular Biology, oxidative stress (OS), reactive oxygen and nitrogen species, human metabotype, Mechanism (biology), EA-enriched food supplements, lcsh:RM1-950, Cell Biology, Bioavailability, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, ellagic acid (EA), chemistry, Polyphenol, 030220 oncology & carcinogenesis, Fruits and vegetables, urolithins, Oxidative stress, Ellagic acid |
| الوصف: | Oxidative stress (OS), triggered by overproduction of reactive oxygen and nitrogen species, is the main mechanism responsible for several human diseases. The available one-target drugs often face such illnesses, by softening symptoms without eradicating the cause. Differently, natural polyphenols from fruits and vegetables possess multi-target abilities for counteracting OS, thus representing promising therapeutic alternatives and adjuvants. Although in several in vitro experiments, ellagitannins (ETs), ellagic acid (EA), and its metabolites urolithins (UROs) have shown similar great potential for the treatment of OS-mediated human diseases, only UROs have demonstrated in vivo the ability to reach tissues to a greater extent, thus appearing as the main molecules responsible for beneficial activities. Unfortunately, UROs production depends on individual metabotypes, and the consequent extreme variability limits their potentiality as novel therapeutics, as well as dietary assumption of EA, EA-enriched functional foods, and food supplements. This review focuses on the pathophysiology of OS; on EA and UROs chemical features and on the mechanisms of their antioxidant activity. A discussion on the clinical applicability of the debated UROs in place of EA and on the effectiveness of EA-enriched products is also included. |
| تدمد: | 2076-3921 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df66c14f1c021fd4fa6e4013cf0b2f50 https://pubmed.ncbi.nlm.nih.gov/32759749 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df66c14f1c021fd4fa6e4013cf0b2f50 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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