Extracellular nucleotides and P2 receptors in renal function
| العنوان: | Extracellular nucleotides and P2 receptors in renal function |
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| المؤلفون: | Bellamkonda K. Kishore, Jens Leipziger, Robert J. Unwin, Edward W. Inscho, Volker Vallon |
| المصدر: | Vallon, V, Unwin, R, Inscho, E W, Leipziger, J & Kishore, B K 2020, ' Extracellular nucleotides and P2 receptors in renal function ', Physiological Reviews, vol. 100, no. 1, pp. 211-269 . https://doi.org/10.1152/physrev.00038.2018 Physiol Rev |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | P2 receptors, P2Y receptor, Physiology, Renal function, Review Article, 030204 cardiovascular system & hematology, P2 receptor, Kidney, 03 medical and health sciences, Adenosine Triphosphate, 0302 clinical medicine, Physiology (medical), medicine, Extracellular, Animals, Humans, Nucleotide, Transport function, Receptor, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Receptors, Purinergic P2, Nucleotides, General Medicine, Cell biology, Renal hemodynamics, medicine.anatomical_structure, chemistry, Function (biology), Signal Transduction |
| الوصف: | The understanding of the nucleotide/P2 receptor system in the regulation of renal hemodynamics and transport function has grown exponentially over the last 20 yr. This review attempts to integrate the available data while also identifying areas of missing information. First, the determinants of nucleotide concentrations in the interstitial and tubular fluids of the kidney are described, including mechanisms of cellular release of nucleotides and their extracellular breakdown. Then the renal cell membrane expression of P2X and P2Y receptors is discussed in the context of their effects on renal vascular and tubular functions. Attention is paid to effects on the cortical vasculature and intraglomerular structures, autoregulation of renal blood flow, tubuloglomerular feedback, and the control of medullary blood flow. The role of the nucleotide/P2 receptor system in the autocrine/paracrine regulation of sodium and fluid transport in the tubular and collecting duct system is outlined together with its role in integrative sodium and fluid homeostasis and blood pressure control. The final section summarizes the rapidly growing evidence indicating a prominent role of the extracellular nucleotide/P2 receptor system in the pathophysiology of the kidney and aims to identify potential therapeutic opportunities, including hypertension, lithium-induced nephropathy, polycystic kidney disease, and kidney inflammation. We are only beginning to unravel the distinct physiological and pathophysiological influences of the extracellular nucleotide/P2 receptor system and the associated therapeutic perspectives. |
| اللغة: | English |
| DOI: | 10.1152/physrev.00038.2018 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0adc31f35b91d7de969bf7c09348b9 https://pure.au.dk/portal/da/publications/extracellular-nucleotides-and-p2-receptors-in-renal-function(dfd90454-4413-4fe9-bd95-58a59494d5cd).html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df0adc31f35b91d7de969bf7c09348b9 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1152/physrev.00038.2018 |
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