Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins
| العنوان: | Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins |
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| المؤلفون: | Rubens J. Nascimento, Jaime M. Santana, Carla Nunes de Araújo, Silene P. Lozzi, Antonio R. L. Teixeira |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 65:219-226 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, Rural Population, Chagas disease, Saliva, Urban Population, Blotting, Western, Salivary Glands, Cohort Studies, Virology, parasitic diseases, Triatoma infestans, medicine, Animals, Humans, Chagas Disease, Triatoma, integumentary system, biology, Salivary gland, fungi, biology.organism_classification, medicine.disease, Culex, Infectious Diseases, medicine.anatomical_structure, Reduviidae, Immunoglobulin G, Immunology, biology.protein, Insect Proteins, Female, Parasitology, Antibody, Trypanosomiasis, Brazil |
| الوصف: | The Triatoma infestans salivary gland proteins (TSGP) can induce local and systemic hypersensitivity reactions in humans. IgG antibodies against TSGP were present in higher levels in sera of Chagas disease patients, and in individuals living in triatomine-infested areas than in controls living in triatomine-free areas. TSGP-specific IgG1 was found in sera of Chagas patients, and of individuals living in triatomine-infested rural areas, and uniquely specific IgG4 was present in sera of Chagas patients living in triatomine-infested areas, reactive against TSGP. Unique specificities were not detected in sera of individuals reacting against the ubiquitous mosquito Culex quinquifasciatus saliva proteins (CSGP). In conclusion, IgG1 reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG4 is found in the sera of insect-transmitted Chagas disease patients living in study areas. |
| تدمد: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2001.65.219 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8e058bd727db754134d9718b3cb4e3 https://doi.org/10.4269/ajtmh.2001.65.219 |
| رقم الانضمام: | edsair.doi.dedup.....de8e058bd727db754134d9718b3cb4e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.2001.65.219 |