A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility
| العنوان: | A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility |
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| المؤلفون: | Yixian Zhou, Jintao Fu, Biyuan Wu, Xin Pan, Yiting Zhao, Chuanbin Wu, Boyi Niu, Sulan Luo, Guilan Quan |
| المصدر: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2404-2416 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | PVP, poly(vinyl pyrrolidone), Metal-organic framework, Nanoporous particle, CD-MOF-K, ketoprofen-loaded cyclodextrin-based metal-organic framework, BET, Brunauer–Emmett–Teller, 0302 clinical medicine, γ-CD, γ-cyclodextrin, HE, Hematoxylin-Eosin, BALF, bronchoalveolar lavage fluid, MFI, mean fluorescence intensity, General Pharmacology, Toxicology and Pharmaceutics, Inhalable dry powder, Aerosolization, ANOVA, analysis of variance, SD rat, Sprague–Dawley rat, chemistry.chemical_classification, 0303 health sciences, Cyclodextrin, Inhalation, LDH, lactate dehydrogenase, Nanoporous, DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, MMAD, mean mass aerodynamic diameter, NGI, next generation pharmaceutical impactor, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, Drug delivery, LPS, lipopolysaccharide, Original Article, Materials science, Biocompatibility, Nanotechnology, PBS, phosphate buffered solution, Lung injury, CF, commercial formulation, 03 medical and health sciences, CCK-8, cell counting kit-8, FBS, fetal bovine serum, SEM, scanning electron microscopy, 030304 developmental biology, CD-MOF-R, rhodamine B-loaded cyclodextrin-based metal-organic framework, lcsh:RM1-950, fungi, CTAB, cetyl trimethyl ammonium bromide, PXRD, powder X-ray diffraction, Cdyn, dynamic lung compliance, GSD, geometric standard deviation, Pulmonary drug delivery, FPF, fine particle fraction, Rl, lung resistance, SLF, simulated lung fluid, Bioavailability, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, CD-MOF, cyclodextrin-based metal-organic framework, chemistry, MOF, metal-organic framework |
| الوصف: | Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens. Compared with commercial inhalation carrier, CD-MOF showed excellent aerosolization performance because of the homogenous nanoporous structure. The great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments, including cytotoxicity assay, hemolysis ratio test, lung function evaluation, in vivo lung injury markers measurement, and histological analysis. The results of ex vivo fluorescence imaging showed the high deposition rate of CD-MOF in lungs. Therefore, all results demonstrated that CD-MOF was a promising carrier for pulmonary drug delivery. This study may throw light on the nanoporous particles for effective pulmonary administration. Graphical abstract The nanoporous CD-MOF particles were delicately engineered for pulmonary drug delivery. Compared with commercial inhalation carrier, CD-MOF showed better aerodynamic behavior and higher lung deposition rate because of the homogenous nanoscale pores. Moreover, CD-MOF exhibited good biocompatibility, which would not affect the lung function and cause inflammatory response.Image 1 |
| تدمد: | 2211-3835 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de290deb599c1006e737c65e46bd503b https://pubmed.ncbi.nlm.nih.gov/33354510 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....de290deb599c1006e737c65e46bd503b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113835 |
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