Polymyalgia rheumatica: A case series from Colombia and analysis of Latin America
| العنوان: | Polymyalgia rheumatica: A case series from Colombia and analysis of Latin America |
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| المؤلفون: | Milly J. Vecino, Santiago Beltrán, Mónica Rodríguez-Jiménez, Rubén D. Mantilla, Carlos Enrique Toro-Gutiérrez, Manuel Rojas, Carlos Alberto Cañas, Vivian Pastrana-Gonzalez |
| المصدر: | Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100115-(2021) Journal of Translational Autoimmunity |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, CI, Confidence interval, PMR, Polymyalgia rheumatica, Immunology, education, GCA, Giant cell arteritis, MTX, Methotrexate, Malignancy, Article, Polymyalgia rheumatica, OR, Odds ratio, GCs, Glucocorticoids, CRP, C-reactive protein, RF, Rheumatoid factor, Internal medicine, Neoplasms, medicine, Immunology and Allergy, Meta-regression, ts-DMARDs, Targeted-synthetic disease-modifying antirheumatic drugs, skin and connective tissue diseases, SD, Standard deviation, Giant cell arteritis, business.industry, Medical record, LATAM, Latin America, Retrospective cohort study, PRISMA, Preferred Reporting Items for Systematic Reviews and Meta‐analyses, RC581-607, medicine.disease, Polyautoimmunity, Rheumatology, CART, Classification and regression trees, DMARDs, Disease-modifying antirheumatic drugs, Latin America, Systematic review, ACPA, Cyclic citrullinated peptide antibody, PolyA, Polyautoimmunity, EULAR/ACR, European League Against Rheumatism/American College of Rheumatology, IQR, Interquartile range, Immunologic diseases. Allergy, business, ANAs, Antinuclear antibodies, ESR, Erythrocyte sedimentation rate, Rheumatism |
| الوصف: | Objective Polymyalgia rheumatica (PMR) is the most common inflammatory disease in patients over 50 years. Information about the disease in Latin America (LATAM) is scarce. We aimed to evaluate a group of Colombian patients with PMR and to conduct a systematic review of PMR in LATAM. Methods A multicentric retrospective study was performed. Medical records of 256 PMR patients were evaluated. Patients were divided into two groups, those fulfilling the 2012 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for PMR and those who did not (i.e., clinical diagnosis). A systematic literature review and meta regression was performed comparing Colombian vs LATAM patients. Results From 256 patients, 145 (56.6%) fulfilled the 2012 EULAR/ACR criteria, and 111 (43.3%) were classified by clinical diagnosis. Inflammatory bilateral shoulder pain, pelvic girdle aching, morning stiffness >45 min, elevated erythrocyte sedimentation rate (ESR), and C-reactive protein (CPR), and Methotrexate (MTX) prescription were more common in the 2012 EULAR/ACR group. None of the included patients presented overt polyautoimmunity (PolyA), whereas up to 24% exhibited latent PolyA. In addition, these patients showed high frequency of malignancy (7.59%). In the meta regression analysis, Colombian patients exhibited lower ESR levels, and were less likely to develop giant cell arteritis (GCA) as compared to the rest of LATAM data. Conclusion Patients with PMR in LATAM exhibit similar phenotypes from other cohorts worldwide. Malignancy, GCA and latent PolyA should be considered in the routine clinical follow-up of patients with PMR. Highlights • Pelvic girdle aching and inflammatory markers are key factors for polymyalgia rheumatica (PMR) classification. • Patients with PMR classified by 2012 EULAR/ACR criteria were more likely to present malignancy. • Up to 24% of patients with PMR exhibit latent polyautoimmunity. • Colombian patients show less inflammation and frequency of giant cell arteritis than the rest of Latin America. |
| اللغة: | English |
| تدمد: | 2589-9090 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0a4c433d5b284298d14fbddda00c26 http://www.sciencedirect.com/science/article/pii/S2589909021000356 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....de0a4c433d5b284298d14fbddda00c26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25899090 |
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