Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia
| العنوان: | Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia |
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| المؤلفون: | Edward Giovannucci, Chris S. Carlson, Christopher A. Haiman, Holli H. Dilks, Charles Kooperberg, Mathieu Lemire, Steven Gallinger, David Duggan, Noralane M. Lindor, Lynne R. Wilkens, Gowri Kumaraguruparan, Robert W. Haile, Michael Hoffmeister, Andrew T. Chan, Lucia A. Hindorff, Thomas J. Hudson, Richard B. Hayes, Fredrick R. Schumacher, José Luis Ambite, Cara L. Carty, Loic Le Marchand, Sonja I. Berndt, Gerardo Heiss, Ulrike Peters, Sue L. Mann, Stéphane Bézieau, Danielle M. Richardson, Paxton Baker, John L. Hopper, Polly A. Newcomb, Stephen J. Chanock, Martha L. Slattery, Sungshim L. Park, John D. Potter, Shuo Jiao, Yi Lin, Bette J. Caan, Jenny Chang-Claude, Dana C. Crawford, Christy L. Avery, Daniela Seminara, Tabitha A. Harrison, Carolyn M. Hutter, David V. Conti, Logan Dumitrescu, Iona Cheng, Robert Goodloe, Li Hsu, Emily White, Peter T. Campbell, Kristine R. Monroe, Robert E. Schoen, Anne M. Butler, Peter Kraft, Graham Casey, Hermann Brenner, Christian Caberto, Sébastien Küry, Brent W. Zanke, Charles S. Fuchs, William S. Bush, John A. Baron, Mark A. Jenkins, Jing Ma, Shelly Ann Love, Lifang Hou, Jonathan M. Kocarnik |
| المصدر: | Gut. 63:800-807 |
| بيانات النشر: | BMJ, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Genetic Markers, Male, Genotyping Techniques, Colorectal cancer, Population, Genome-wide association study, Single-nucleotide polymorphism, Biology, Bioinformatics, Polymorphism, Single Nucleotide, Article, Prostate cancer, Risk Factors, medicine, Humans, SNP, Genetic Predisposition to Disease, Registries, education, Aged, Genetic association, Principal Component Analysis, education.field_of_study, Gastroenterology, Genetic Pleiotropy, Middle Aged, medicine.disease, Logistic Models, Genetic epidemiology, Female, Colorectal Neoplasms, Chromosomes, Human, Pair 8, Genome-Wide Association Study |
| الوصف: | Objective Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be associated with colorectal cancer. In a large-scale study, we examined 171 SNPs previously associated with 18 different cancers for their associations with colorectal cancer. Design We examined 13 338 colorectal cancer cases and 40 967 controls from three consortia: Population Architecture using Genomics and Epidemiology (PAGE), Genetic Epidemiology of Colorectal Cancer (GECCO), and the Colon Cancer Family Registry (CCFR). Study-specific logistic regression results, adjusted for age, sex, principal components of genetic ancestry, and/or study specific factors (as relevant) were combined using fixed-effect meta-analyses to evaluate the association between each SNP and colorectal cancer risk. A Bonferroni-corrected p value of 2.92×10 −4 was used to determine statistical significance of the associations. Results Two correlated SNPs—rs10090154 and rs4242382—in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk. The most significant association was observed with rs4242382 (meta-analysis OR=1.12; 95% CI 1.07 to 1.18; p=1.74×10 −5 ), which also demonstrated similar associations across racial/ethnic populations and anatomical sub-sites. Conclusions This is the first study to clearly demonstrate Region 1 of chromosome 8q24 as a susceptibility locus for colorectal cancer; thus, adding colorectal cancer to the list of cancer sites linked to this particular multicancer risk region at 8q24. |
| تدمد: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gutjnl-2013-305189 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf487b68d8a8b973cb2a6cc8d0f6cdb https://doi.org/10.1136/gutjnl-2013-305189 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ddf487b68d8a8b973cb2a6cc8d0f6cdb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683288 00175749 |
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| DOI: | 10.1136/gutjnl-2013-305189 |