IL-6 −174G>C polymorphism and cancer risk: a meta-analysis involving 29,377 cases and 37,739 controls
| العنوان: | IL-6 −174G>C polymorphism and cancer risk: a meta-analysis involving 29,377 cases and 37,739 controls |
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| المؤلفون: | Jun Tao, Zengjun Wang, Xinru Wang, Xiaobing Niu, Zhengdong Zhang, Zi-Dun Wang, Pengchao Li, Na Tong, Wei Zhang, Zhi-Chao Min, Bin Xu, Lixin Hua, Hong-Fei Wu, Yuan-Yuan Mi, Ninghan Feng, Wei Cheng |
| المصدر: | Molecular Biology Reports. 38:2589-2596 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Black People, Bioinformatics, Polymorphism, Single Nucleotide, Gastroenterology, White People, Asian People, Neoplasms, Internal medicine, Genotype, Odds Ratio, Genetics, medicine, Humans, Genetic Predisposition to Disease, Interleukin 6, Prospective cohort study, Molecular Biology, Bladder cancer, biology, Interleukin-6, business.industry, General Medicine, Odds ratio, medicine.disease, Confidence interval, Meta-analysis, biology.protein, Etiology, Female, business |
| الوصف: | Interleukin-6 (IL-6) is a multifunctional cytokine involved in different physiologic and pathophysiologic processes and plays important roles in the etiology of cancer. The -174G>C polymorphism of the IL-6 gene influences IL-6 transcription and has been implicated in cancer risk. However, published data have been conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 29,377 cancer cases and 37,739 controls from 50 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between -174G>C polymorphism and cancer risk. Overall meta-analysis indicated that no association was found between -174G>C genotypes and cancer risk. However, the positive association was found in bladder cancer (OR=4.33, 95% CI: 1.93-9.71 for CC vs. GC, OR=2.81, 95% CI: 1.39-5.68 for CC vs. GG, and OR=2.19, 95% CI: 1.32-3.64 for CC vs. GG/GC), and among Asians (OR=2.08, 95% CI: 1.07-4.06 for CC vs. GG, and OR=2.20, 95% CI: 1.02-4.74 for CC vs. GG/GC) and Africans (OR=1.61, 95% CI: 1.07-2.42 for GC vs. GG). This meta-analysis showed the evidence that the -174G>C of the IL-6 gene was a low-penetrance susceptibility gene for bladder cancer. Further larger, preferably prospective studies are needed to confirm this relationship. |
| تدمد: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-010-0399-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddb77bd4a81f9d784d6442a5afc5272 https://doi.org/10.1007/s11033-010-0399-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....dddb77bd4a81f9d784d6442a5afc5272 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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| DOI: | 10.1007/s11033-010-0399-1 |