ERBB4 acts as a suppressor in the development of hepatocellular carcinoma

التفاصيل البيبلوغرافية
العنوان: ERBB4 acts as a suppressor in the development of hepatocellular carcinoma
المؤلفون: Tong Shen, Qun Zhou, Tian-Ming Gao, Yao Liu, Weijuan Jiao, Li-Na Sun, Liming Song, Hongxia Cui, Hengli Ni, Jian-Ming Li, Lin Chen
المصدر: Carcinogenesis. 38:465-473
بيانات النشر: Oxford University Press (OUP), 2017.
سنة النشر: 2017
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Carcinoma, Hepatocellular, Receptor, ErbB-4, Liver tumor, Down-Regulation, Apoptosis, Mice, 03 medical and health sciences, Hepatitis B, Chronic, Liver Neoplasms, Experimental, 0302 clinical medicine, Cell Line, Tumor, Carcinoma, medicine, Animals, Humans, Epidermal growth factor receptor, ERBB4, Cell Proliferation, Mice, Knockout, biology, Microarray analysis techniques, business.industry, Tumor Suppressor Proteins, Liver Neoplasms, Hep G2 Cells, General Medicine, Hepatitis B, Prognosis, medicine.disease, digestive system diseases, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Knockout mouse, Cancer research, biology.protein, business
الوصف: ERBB4, one member of the epidermal growth factor receptor (EGFR) family, plays a key role in physiological and pathological processes. Recently, we identified that ERBB4 played a protective role from chronic hepatitis B virus infection. However, the role of ERBB4 in hepatocellular carcinoma (HCC) is still unclear. Here, we explore the role of ERBB4 in the development of HCC using in vitro models, in vivo animal models and clinical samples of HCC. Liver-specific ERBB4 knockout alleles and full ERBB4 except heart knockout mice were used in this study. Liver inflammation and tumor models of mice were produced by carbon tetrachloride (CCl4) and diethylnitrosamine (DEN) administration, respectively. Commercial tissue arrays of 90 HCC patients with paired counterparts were used to evaluate the expression and the prognostic value of ERBB4. Genes altered in the setting of ERBB4 loss was studied by microarray analysis and further validated by real-time PCR. We have found that depletion of ERBB4 in mice leads to more severe injury and liver tumor formation and loss of ERBB4 contributes to the development of hepatocellular tumor. In clinic samples of HCC, ERBB4 is down-regulated and exhibit prognostic value of HCC patients. Mechanistically, loss of ERBB4 suppressed p53 expression by inhibiting the expression of the tumor suppressor tp53inp1. Our study uncovers ERBB4 as a suppressor in the development of HCC and implies an ERBB4-TP53INP1-P53 axis in HCC.
تدمد: 1460-2180
0143-3334
DOI: 10.1093/carcin/bgx017
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9cd271e92d47039cee19544e34924c
https://doi.org/10.1093/carcin/bgx017
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....dd9cd271e92d47039cee19544e34924c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14602180
01433334
DOI:10.1093/carcin/bgx017