Safety evaluation of Veillonella atypica FB0054 with genotoxicity and subchronic toxicological studies
| العنوان: | Safety evaluation of |
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| المؤلفون: | Kayla E. Preece, Róbert Glávits, Timothy S. Murbach, John R. Endres, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné |
| المصدر: | Journal of Applied Toxicology. 43:808-827 |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Toxicology |
| الوصف: | Veillonella atypica is a nonmotile, nonsporulating anaerobic bacteria commonly found in various human biofilms. V. atypica FB0054 was isolated from the gastrointestinal tract of marathon runners, who have increased amounts of this species after athletic events. Interestingly, the consumption of this strain by rodents has been shown to increase their treadmill endurance, leading to the hypothesis that consumption of this species may improve athletic performance in humans as well. Further evaluation, in humans, of the usefulness of this strain should be preceded by safety studies. Therefore, the genotoxic and subchronic toxicological potential was evaluated as a contribution to this effort. Genotoxicity investigation was performed using the in vivo comet assay and in vivo mammalian micronucleus assay due to the anaerobic characteristic of the strain. A 90-day repeated-dose oral toxicity study was performed in rats up to 2200 mg/kg bw/d to investigate general toxicity and identify any target organs. Mitsuoka buffer, a solution shown to preserve the viability of anaerobic bacteria, was used as the vehicle. All three studies revealed no toxicological effects from exposure to V. atypica FB0054 at the highest doses tested. |
| تدمد: | 1099-1263 0260-437X |
| DOI: | 10.1002/jat.4426 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd980696b575364286b7b2d10873f67c https://doi.org/10.1002/jat.4426 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....dd980696b575364286b7b2d10873f67c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991263 0260437X |
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| DOI: | 10.1002/jat.4426 |