Measuring vaccine effectiveness against persistent HPV infections: a comparison of different statistical approaches
| العنوان: | Measuring vaccine effectiveness against persistent HPV infections: a comparison of different statistical approaches |
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| المؤلفون: | Petra J. Woestenberg, Joske Hoes, A. J. King, Gina Ogilvie, Chris J.L.M. Meijer, Robine Donken, M.J. Knol, Simon Dobson, Johannes A. Bogaards, H.E. de Melker, Joel Singer |
| المساهمون: | CCA - Cancer Treatment and quality of life, Pathology, AII - Infectious diseases, APH - Methodology, RS: CAPHRI - R4 - Health Inequities and Societal Participation |
| المصدر: | Donken, R, Hoes, J, Knol, M J, Ogilvie, G S, Dobson, S, King, A J, Singer, J, Woestenberg, P J, Bogaards, J A, Meijer, C J L M & De Melker, H E 2020, ' Measuring vaccine effectiveness against persistent HPV infections : a comparison of different statistical approaches ', BMC Infectious Diseases, vol. 20, no. 1, 482 . https://doi.org/10.1186/s12879-020-05083-7 BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020) BMC Infectious Diseases, 20(1):482. BioMed Central BMC Infectious Diseases BMC Infectious Diseases, 20(1):482. BioMed Central Ltd |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pediatrics, SUSTAINED EFFICACY, Poisson distribution, DOUBLE-BLIND, Immunogenicity, Vaccine, 0302 clinical medicine, Medical microbiology, Prevalence, Longitudinal Studies, 030212 general & internal medicine, Generalized estimating equation, CROSS-PROTECTIVE EFFICACY, Human papillomavirus 18, Follow-up, Vaccination, YOUNG-WOMEN, HPV-16/18 AS04-ADJUVANTED VACCINE, Exact test, Treatment Outcome, Infectious Diseases, PATRICIA RANDOMIZED-TRIAL, 030220 oncology & carcinogenesis, Cohort, symbols, Female, Research Article, Adult, HPV, Human papillomavirus, medicine.medical_specialty, Adolescent, Persistent infection, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, symbols.namesake, CERVICAL COINFECTION, medicine, Humans, lcsh:RC109-216, Human papillomavirus 31, Papillomavirus Vaccines, Poisson regression, PARTICLE VACCINE, HUMAN-PAPILLOMAVIRUS TYPE-16, HPV vaccination, business.industry, Papillomavirus Infections, Binomial distribution, Observational study, business, Follow-Up Studies |
| الوصف: | Background Persistent high-risk human papillomavirus (HPV) infection is endorsed by the World Health Organization as an intermediate endpoint for evaluating HPV vaccine effectiveness/efficacy. There are different approaches to estimate the vaccine effectiveness/efficacy against persistent HPV infections. Methods We performed a systematic literature search in Pubmed to identify statistical approaches that have been used to estimate the vaccine effectiveness/efficacy against persistent HPV infections. We applied these methods to data of a longitudinal observational study to assess their performance and compare the obtained vaccine effectiveness (VE) estimates. Results Our literature search identified four approaches: the conditional exact test for comparing two independent Poisson rates using a binomial distribution, Generalized Estimating Equations for Poisson regression, Prentice Williams and Peterson total time (PWP-TT) and Cox proportional hazards regression. These approaches differ regarding underlying assumptions and provide different effect measures. However, they provided similar effectiveness estimates against HPV16/18 and HPV31/33/45 persistent infections in a cohort of young women eligible for routine HPV vaccination (range VE 93.7–95.1% and 60.4–67.7%, respectively) and seemed robust to violations of underlying assumptions. Conclusions As the rate of subsequent infections increased in our observational cohort, we recommend PWP-TT as the optimal approach to estimate the vaccine effectiveness against persistent HPV infections in young women. Confirmation of our findings should be undertaken by applying these methods after longer follow-up in our study, as well as in different populations. |
| اللغة: | English |
| تدمد: | 1471-2334 |
| DOI: | 10.14288/1.0392353 |
| DOI: | 10.1186/s12879-020-05083-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6816bbdbbcfa1b51f8984ecc1ec90c |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd6816bbdbbcfa1b51f8984ecc1ec90c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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| DOI: | 10.14288/1.0392353 |