Developmental Sex Differences in Estrogen Receptor-β mRNA Expression in the Mouse Hypothalamus/Preoptic Region
| العنوان: | Developmental Sex Differences in Estrogen Receptor-β mRNA Expression in the Mouse Hypothalamus/Preoptic Region |
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| المؤلفون: | Magdalena Karolczak, Cordian Beyer |
| المصدر: | Neuroendocrinology. 68:229-234 |
| بيانات النشر: | S. Karger AG, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Mrna expression, Cell, Hypothalamus, Biology, Mice, Cellular and Molecular Neuroscience, Sex Factors, Endocrinology, Internal medicine, Mouse Hypothalamus, medicine, Animals, Estrogen Receptor beta, Preoptic region, RNA, Messenger, Estrogen receptor beta, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Endocrine and Autonomic Systems, Gene Expression Regulation, Developmental, Preoptic Area, Sexual dimorphism, Preoptic area, Blotting, Southern, medicine.anatomical_structure, Receptors, Estrogen, Female, Estrogen receptor alpha |
| الوصف: | Estrogens play a significant role during mammalian brain development and are required for the masculinization of neuronal circuits involved in sex-specific behaviors and neuroendocrine functions. Cellular estrogen signalling is transmitted through nuclear estrogen receptors (ER) which are divided into two subforms: the ER-alpha as well as the recently cloned ER-beta have been demonstrated in the hypothalamus. In the present study, we have analyzed the sex-specific expression of ER-beta mRNA in the pre- and postnatal mouse hypothalamus/preoptic region (Hyp/POA) by semiquantitative RT-PCR. The ER-beta mRNA was detectable as early as embryonic day (E) 15 in the diencephalon of both sexes. In males, levels of mRNA expression in the Hyp/POA increased until birth and remained high throughout postnatal (P) development, whereas in females, such an increase was not observed. Significantly higher mRNA levels were detected in the male Hyp/POA from E17 until P15. Perinatal sex differences in ER-beta mRNA expression coincide with higher estrogen-forming rates in the male Hyp/POA. At present, no direct evidence is available which demonstrates that estrogen signalling through ER-beta is involved in brain development. However, data from our and other studies suggest a potential role for this signal transduction pathway for brain differentiation. |
| تدمد: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000054370 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf2210fd239ebfd35d5ab0f19605113 https://doi.org/10.1159/000054370 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....dcf2210fd239ebfd35d5ab0f19605113 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230194 00283835 |
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| DOI: | 10.1159/000054370 |