Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation
| العنوان: | Is there a relationship between psoriasis and hepatitis C? A meta-analysis and bioinformatics investigation |
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| المؤلفون: | Xiao Ning Yan, Ye Xia, Sheng Nan Cui, Yi Xing Liu, Zhi Li Dou, Dong Ran Han, Meng Yao Duan, Jia Wei Zhang, Yi Zhen Li, Yong Liu |
| المصدر: | Virology Journal Virology Journal, Vol 18, Iss 1, Pp 1-10 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Infectious and parasitic diseases, RC109-216, Cochrane Library, Biology, Bioinformatics, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Toll-like receptor signaling pathway, Virology, Psoriasis, medicine, Humans, Interleukin 8, Protein Interaction Maps, Research, Computational Biology, Inflammatory response, Hepatitis C, medicine.disease, Interleukin 10, 030104 developmental biology, Infectious Diseases, Cross-Sectional Studies, Meta-analysis, Tumor necrosis factor alpha |
| الوصف: | Background The relationship between psoriasis and hepatitis C was previously controversial, so our purpose is to investigate this connection. Methods We conducted a systematic review of the case–control, cross-sectional and cohort studies examining the association between psoriasis and hepatitis C in PubMed, EMBASE and Cochrane library databases and investigated the overlapping genes between psoriasis targets and hepatitis C targets using bioinformatics analysis. Based on overlapping genes and hub nodes, we also constructed the protein–protein interaction (PPI) network and module respectively, followed by the pathway enrichment analysis. Results We included 11 publications that reported a total of 11 studies (8 cross-sectional and 3 case–control). The case–control and cross-sectional studies included 25,047 psoriasis patients and 4,091,631 controls in total. Psoriasis was associated with a significant increase of prevalent hepatitis C (OR 1.72; 95% confidence interval [CI] (1.17–2.52)). A total of 389 significant genes were common to both hepatitis C and psoriasis, which mainly involved IL6, TNF, IL10, ALB, STAT3 and CXCL8. The module and pathway enrichment analyses showed that the common genes had the potential to influence varieties of biological pathways, including the inflammatory response, cytokine activity, cytokine–cytokine receptor interaction, Toll-like receptor signaling pathway, which play an important role in the pathogenesis of hepatitis C and psoriasis. Conclusion Patients with psoriasis display increased prevalence of hepatitis C and the basic related mechanisms between hepatitis C and psoriasis had been preliminarily clarified. |
| تدمد: | 1743-422X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc7a155415ccd969ef82993cc72258f https://pubmed.ncbi.nlm.nih.gov/34215260 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dcc7a155415ccd969ef82993cc72258f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1743422X |
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