Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients
| العنوان: | Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients |
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| المؤلفون: | Somayeh Mousavi, Mohsen Moohebati, Amir Ali Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Behrooz Mottahedi, Shima Tavallaie, Fatemeh Khorashadizadeh, Roshanak Khojasteh, Jamil Esfehanizadeh, Maral Amini, Roghayeh Paydar, Majid Ghayour-Mobarhan, Amirhossein Sahebkar, Gordon A. Ferns, Ali Azari |
| المصدر: | Medical Principles and Practice |
| بيانات النشر: | S. Karger AG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Cardiac function curve, Cardiac output, medicine.medical_specialty, Heart Valve Diseases, Coronary artery bypass grafting, Coronary Artery Disease, Cardiac Valve Annuloplasty, Immunoglobulin G, Coronary artery disease, Malondialdehyde, Internal medicine, Humans, Medicine, Cardiac Output, Cardiac Surgical Procedures, Coronary Artery Bypass, Pulmonary wedge pressure, Aged, Autoantibodies, Original Paper, Ejection fraction, biology, business.industry, valvular heart disease, Cardiac function, General Medicine, Middle Aged, medicine.disease, Valvular heart disease, Lipoproteins, LDL, Anti-malondialdehyde-modified low-density lipoprotein, medicine.anatomical_structure, Echocardiography, Cardiology, biology.protein, Female, business, Biomarkers, Artery |
| الوصف: | Objective: To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty. Subjects and Methods: A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. Results: In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease. Conclusions: Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG. |
| تدمد: | 1423-0151 1011-7571 |
| DOI: | 10.1159/000431178 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbb07dd1f1cc6a33b8025f830552f21 https://doi.org/10.1159/000431178 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dcbb07dd1f1cc6a33b8025f830552f21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230151 10117571 |
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| DOI: | 10.1159/000431178 |