Prolonged hypoglycemia after a suicidal ingestion of repaglinide with unexpected slow plasma elimination
| العنوان: | Prolonged hypoglycemia after a suicidal ingestion of repaglinide with unexpected slow plasma elimination |
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| المؤلفون: | Roland Elling, Marco Simon Spehl, Ariane Wohlfarth, Maren Hermanns-Clausen, Volker Auwaerter |
| المصدر: | Clinical Toxicology. 54:158-160 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Blood Glucose, Adolescent, medicine.medical_treatment, Poison control, 030209 endocrinology & metabolism, Context (language use), Pharmacology, Hypoglycemia, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Pharmacokinetics, Tandem Mass Spectrometry, Humans, Hypoglycemic Agents, Insulin, Medicine, Ingestion, business.industry, General Medicine, medicine.disease, Repaglinide, Female, Secretagogue, Carbamates, Drug Overdose, business, Chromatography, Liquid, Half-Life, medicine.drug |
| الوصف: | Repaglinide is a short-acting insulin secretagogue with high interindividual variability in pharmacokinetics due to genetic polymorphisms. Little is known about repaglinide overdoses, both with respect to pharmacokinetics and appropriate management. Given its short serum half-life of less than 1 h, hypoglycemic effects of repaglinide are expected to cease within a few hours post-ingestion.A 15-year-old girl ingested 10.5 mg of repaglinide in a suicide attempt. Few hours later, she developed a strong food craving, nausea, abdominal pain, and a headache. The lowest recorded serum glucose was 44 mg/dl (2.4 mmol/l) 14 h post-ingestion. Using liquid chromatography-mass spectrometry, we detected repaglinide serum levels of 5.3, 2.6, and 1.0 ng/ml at 14, 20, and 26 h post-ingestion, respectively.This case illustrates that in the context of overdose, repaglinide can lead to prolonged hypoglycemia. We therefore recommend glucose monitoring and observation for 24 h in all patients who remain hypoglycemic or show symptoms of hypoglycemia for an unusually long period of time. |
| تدمد: | 1556-9519 1556-3650 |
| DOI: | 10.3109/15563650.2015.1122793 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc852cfb8409c02f49d365a07778cf4c https://doi.org/10.3109/15563650.2015.1122793 |
| رقم الانضمام: | edsair.doi.dedup.....dc852cfb8409c02f49d365a07778cf4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15569519 15563650 |
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| DOI: | 10.3109/15563650.2015.1122793 |