Porcine mesothelium matrix as a biomaterial for wound healing applications
| العنوان: | Porcine mesothelium matrix as a biomaterial for wound healing applications |
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| المؤلفون: | M.A. Tilbury, J.G. Wall, Dimitrios I. Zeugolis, Héctor Capella-Monsonís |
| المصدر: | Materials Today Bio Materials Today Bio, Vol 7, Iss, Pp 100057-(2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | PM-MB, porcine mesothelium—Meso Biomatrix®, HUVECs, human umbilical vein endothelial cells, Angiogenesis, LB, lysogenic broth, Biomedical Engineering, PBS, phosphate-buffered saline, PUB-MS, porcine urinary bladder—MatriStem®, Bioengineering, 02 engineering and technology, Matrix metalloproteinase, Matrix (biology), CORC-PG, collagen/oxidized regenerated cellulose—Promogran™, Functional biomaterials, Biomaterials, Extracellular matrix, Dermal fibroblast, 03 medical and health sciences, Full Length Article, medicine, PM-PC, porcine mesothelium—Puracol® Ultra ECM, Immune response, lcsh:QH301-705.5, Molecular Biology, 030304 developmental biology, SDS-PAGE, sodium dodecyl sulphate–polyacrylamide gel electrophoresis, Xenografts, lcsh:R5-920, 0303 health sciences, Chemistry, Biomaterial, Cell Biology, 021001 nanoscience & nanotechnology, Cell biology, ECM, extracellular matrix, Mesothelium, Collagen devices, medicine.anatomical_structure, lcsh:Biology (General), P/S, penicillin/streptomycin, DMEM, Dulbecco's modified eagle medium, LPS, lipopolysaccharides, PFA, paraformaldehyde, lcsh:Medicine (General), 0210 nano-technology, Wound healing, OF-EF, ovine forestomach—Endoform™, Biotechnology |
| الوصف: | The increasing economic burden of wound healing in healthcare systems requires the development of functional therapies. Xenografts with preserved extracellular matrix (ECM) structure and biofunctional components overcome major limitations of autografts and allografts (e.g. availability) and artificial biomaterials (e.g. foreign body response). Although porcine mesothelium is extensively used in clinical practice, it is under-investigated for wound healing applications. Herein, we compared the biochemical and biological properties of the only two commercially available porcine mesothelium grafts (Meso Biomatrix® and Puracol® Ultra ECM) to traditionally used wound healing grafts (Endoform™, ovine forestomach and MatriStem®, porcine urinary bladder) and biomaterials (Promogran™, collagen/oxidized regenerated cellulose). The Endoform™ and the Puracol® Ultra ECM showed the highest (p0.05) response to enzymatic degradation, whereas the Promogran™ was not completely degraded by matrix metalloproteinase (MMP)-8 and was completely degraded by elastase. The Promogran™ showed the highest (p Graphical abstract Image 1 |
| اللغة: | English |
| تدمد: | 2590-0064 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc57fb6ae836af366f40de533ae96066 http://europepmc.org/articles/PMC7305392 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc57fb6ae836af366f40de533ae96066 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25900064 |
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