التفاصيل البيبلوغرافية
| العنوان: |
Epigenetic inheritance of gene silencing is maintained by a self-tuning mechanism based on resource competition |
| المؤلفون: |
Omer Karin, Eric A. Miska, Benjamin D. Simons |
| المساهمون: |
Simons, Benjamin [0000-0002-3875-7071], Apollo - University of Cambridge Repository |
| بيانات النشر: |
Elsevier BV, 2023. |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
design principles, self organization, Histology, transgenerational inheritance, biological memory, epigenetic memory, mathematical modeling, Inheritance Patterns, systems biology, Cell Biology, dynamical systems, self-tuning to criticality, Pathology and Forensic Medicine, Epigenesis, Genetic, small RNAs, Animals, Gene Silencing, Caenorhabditis elegans, Caenorhabditis elegans Proteins |
| الوصف: |
Biological systems can maintain memories over long timescales, with examples including memories in the brain and immune system. It is unknown how functional properties of memory systems, such as memory persistence, can be established by biological circuits. To address this question, we focus on transgenerational epigenetic inheritance in Caenorhabditis elegans. In response to a trigger, worms silence a target gene for multiple generations, resisting strong dilution due to growth and reproduction. Silencing may also be maintained indefinitely upon selection according to silencing levels. We show that these properties imply the fine-tuning of biochemical rates in which the silencing system is positioned near the transition to bistability. We demonstrate that this behavior is consistent with a generic mechanism based on competition for synthesis resources, which leads to self-organization around a critical state with broad silencing timescales. The theory makes distinct predictions and offers insights into the design principles of long-term memory systems. |
| وصف الملف: |
application/pdf |
| DOI: |
10.17863/cam.93268 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc48854474980cf916659a21a31595a7 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....dc48854474980cf916659a21a31595a7 |
| قاعدة البيانات: |
OpenAIRE |