Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery
| العنوان: | Early Timing of Thyroidectomy for Hyperthyroidism in Graves’ Disease Improves Biochemical Recovery |
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| المؤلفون: | Domenic Vital, Roman D. Laske, Michelle Brown, Christoph Schmid, Christian M Meerwein, Gerhard F. Huber, Hans C. Steinert, Grégoire B. Morand |
| المساهمون: | University of Zurich, Huber, Gerhard F |
| المصدر: | World Journal of Surgery. 41:2545-2550 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Time Factors, Adolescent, endocrine system diseases, medicine.medical_treatment, Graves' disease, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology, 030230 surgery, Hyperthyroidism, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Thyroid storm, Aged, business.industry, Thyroid, Thyroidectomy, 10181 Clinic for Nuclear Medicine, Middle Aged, Vascular surgery, medicine.disease, 10044 Clinic for Radiation Oncology, Graves Disease, 2746 Surgery, Surgery, Cardiac surgery, medicine.anatomical_structure, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Female, business, Abdominal surgery |
| الوصف: | The role of thyroidectomy as an early treatment for hyperthyroidism has been poorly investigated. Our aim was to examine its success rates, particularly focusing on thyroidectomy as an early treatment. Patients with thyroidectomy for hyperthyroidism between February 2008 and October 2014 were included. They were divided into two groups (early and delayed thyroidectomy), and patient characteristics, treatment indications, complications and time to biochemical recovery were analyzed. Ninety-nine patients met the inclusion criteria, of whom 65 (66%) suffered from Graves’ disease, 25 (25%) from toxic goiters and 9 (9%) from amiodarone-induced hyperthyroidism. Structural abnormalities of the thyroid (39 patients, 39%) represented the most frequent indications for thyroidectomy. Forty-six patients (46%) underwent an early and 53 (54%) a delayed surgical approach. Patients with Graves’ disease undergoing early thyroidectomy did not suffer more often from complications but had a significantly faster biochemical recovery after surgery than those with a delayed thyroidectomy, as judged by a shorter time to reach TSH (121 ± 24 vs. 240 ± 31 days, p = 0.007) and fT4 (91 ± 29 vs. 183 ± 31 days p = 0.015) levels in the normal range. As expected, there were no recurrences of hyperthyroidism. Early thyroidectomy was neither associated with permanent complications nor thyroid storm, but with a significantly improved biochemical recovery and therefore has to be recommended early in patients with Graves’ disease. |
| وصف الملف: | 138795.pdf - application/pdf |
| تدمد: | 1432-2323 0364-2313 |
| DOI: | 10.1007/s00268-017-4052-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb8cbb71ebd0035225d0a2cbd47f22 https://doi.org/10.1007/s00268-017-4052-1 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....dbfb8cbb71ebd0035225d0a2cbd47f22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322323 03642313 |
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| DOI: | 10.1007/s00268-017-4052-1 |