Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice
| العنوان: | Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice |
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| المؤلفون: | Yasuhiro Ohshiba, Michinari Yokohama, Choji Taya, Takuya Ueda, Kazuhiro Okumura, Kunie Matsuoka, Sari Suzuki, Yuki Miyasaka, Yoshiaki Kikkawa, Masashi Ishikawa |
| المصدر: | Experimental Animals |
| بيانات النشر: | Japanese Association for Laboratory Animal Science, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, Aging, early-onset hearing loss, quantitative trait loci (QTL), Hearing loss, Original, Quantitative Trait Loci, Biology, Quantitative trait locus, Audiology, DBA/2J, General Biochemistry, Genetics and Molecular Biology, Hearing, Genetic linkage, medicine, otorhinolaryngologic diseases, chromosome 5, Animals, Humans, Genetic Predisposition to Disease, Allele, Hearing Loss, ahllocus, Alleles, Genetics, General Veterinary, Microfilament Proteins, Chromosome, General Medicine, Progressive hearing loss, Cadherins, Mice, Inbred C57BL, Profound hearing loss, Sound, Acoustic Stimulation, Mice, Inbred DBA, Chromosomes, Human, Pair 5, Animal Science and Zoology, medicine.symptom, Carrier Proteins, Lod scores |
| الوصف: | The DBA/2J strain is a model for early-onset, progressive hearing loss in humans, as confirmed in the present study. DBA/2J mice showed progression of hearing loss to low-frequency sounds from ultrasonic-frequency sounds and profound hearing loss at all frequencies before 7 months of age. It is known that the early-onset hearing loss of DBA/2J mice is caused by affects in the ahl (Cdh23(ahl)) and ahl8 (Fscn2(ahl8)) alleles of the cadherin 23 and fascin 2 genes, respectively. Although the strong contributions of the Fscn2(ahl8) allele were detected in hearing loss at 8- and 16-kHz stimuli with LOD scores of 5.02 at 8 kHz and 8.84 at 16 kHz, hearing loss effects were also demonstrated for three new quantitative trait loci (QTLs) for the intervals of 50.3-54.5, 64.6-119.9, and 119.9-137.0 Mb, respectively, on chromosome 5, with significant LOD scores of 2.80-3.91 for specific high-frequency hearing loss at 16 kHz by quantitative trait loci linkage mapping using a (DBA/2J × C57BL/6J) F1 × DBA/2J backcross mice. Moreover, we showed that the contribution of Fscn2(ahl8) to early-onset hearing loss with 32-kHz stimuli is extremely low and raised the possibility of effects from the Cdh23(ahl) allele and another dominant quantitative trait locus (loci) for hearing loss at this ultrasonic frequency. Therefore, our results suggested that frequency-specific QTLs control early-onset hearing loss in DBA/2J mice. |
| اللغة: | English |
| تدمد: | 1881-7122 1341-1357 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db929fb7465029584e7e2573f2cd5389 http://europepmc.org/articles/PMC4547997 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db929fb7465029584e7e2573f2cd5389 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18817122 13411357 |
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