Effects of desvenlafaxine on blood pressure in patients treated for major depressive disorder: a pooled analysis
| العنوان: | Effects of desvenlafaxine on blood pressure in patients treated for major depressive disorder: a pooled analysis |
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| المؤلفون: | Karen A Tourian, Jonathan Sporn, Michael E. Thase, Rana Fayyad, Matthieu Boucher, Ru-fong J. Cheng, Christine J. Guico-Pabia |
| المصدر: | Current Medical Research and Opinion. 31:809-820 |
| بيانات النشر: | Informa Healthcare, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Supine position, Blood Pressure, Placebo, Double-Blind Method, Desvenlafaxine Succinate, medicine, Humans, Adverse effect, Randomized Controlled Trials as Topic, Depressive Disorder, Major, business.industry, Incidence (epidemiology), Repeated measures design, General Medicine, Middle Aged, Cyclohexanols, medicine.disease, Antidepressive Agents, Desvenlafaxine, Treatment Outcome, Blood pressure, Anesthesia, Hypertension, Major depressive disorder, Female, business, medicine.drug |
| الوصف: | To evaluate the effect of the serotonin-norepinephrine re-uptake inhibitor desvenlafaxine on blood pressure and incidence of new onset hypertension in pooled short-term studies and in two longer-term, randomized withdrawal studies.Data from patients randomly assigned to desvenlafaxine 10 mg to 400 mg/day or placebo in 11 short-term (8-12 weeks), fixed-dose, double-blind, placebo-controlled studies of major depressive disorder (MDD) were pooled for analysis; two desvenlafaxine randomized withdrawal studies (36 and 46 weeks) were analyzed separately.www.clinicaltrials.gov , NCT00072774, NCT00073762, NCT00277823, NCT00300378, NCT00384033, NCT00798707, NCT00863798, NCT01121484, NCT00824291, NCT01432457, NCT00075257, NCT00887224.Outcomes included change from baseline in supine systolic blood pressure (SSBP) and supine diastolic blood pressure (SDBP), assessed using a mixed model repeated measures (MMRM) analysis, and incidence of hypertension (defined as three consecutive second SDBP measures ≥90 mm Hg AND increase of ≥10 mm Hg from baseline and/or SSBP ≥140 mm Hg AND increase of ≥10 mm Hg), analyzed using Cochran Mantel Hanzael tests. Potential predictors of change in SSBP and SDBP at LOCF were examined by including predictor variables in a regression model.In the pooled, short-term studies, mean changes from baseline over time in SSBP and SDBP were statistically significant compared with placebo for the desvenlafaxine doses of 10 mg/day or greater for SSBP (p ≤ 0.0004; MMRM) and 25 mg/day or greater for SDBP (p ≤ 0.0449; MMRM). The proportion of patients with new onset hypertension differed significantly from placebo for the 50, 200, and 400 mg/day doses (1.9%, 2.4%, 4.8%, respectively, vs 0.8%; all p ≤ 0.0244). Predictors of change in BP included baseline SDBP, baseline SSBP, dose, body mass index, gender, age, race, and history of hypertension.Data were pooled from studies which differed somewhat in study design and patient demographics. None of the studies were originally designed to examine treatment effects on BP. Study entry criteria limit generalization of these results to medically stable patients with a primary diagnosis of MDD.Short-term desvenlafaxine treatment was associated with small but statistically significant increases in SSBP and SDBP. |
| تدمد: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007995.2015.1020365 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa00ffdf8bf6199eea3b4584f01c71a https://doi.org/10.1185/03007995.2015.1020365 |
| رقم الانضمام: | edsair.doi.dedup.....daa00ffdf8bf6199eea3b4584f01c71a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14734877 03007995 |
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| DOI: | 10.1185/03007995.2015.1020365 |