التفاصيل البيبلوغرافية
العنوان:
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists
المؤلفون:
Jack J. Kinsora , Jared B.J. Milbank , Rachel M. Brooker , Christopher S. Knauer , Kenneth S. Kilgore , Cleo J. C. Connolly , John A. Wendt , Corinne E. Augelli-Szafran , Koji Yamagata , Susan E. Bove , Mickelson John , Paul Galatsis , Roy D. Schwarz
المصدر:
Bioorganic & Medicinal Chemistry Letters . 17:6525-6528
بيانات النشر:
Elsevier BV, 2007.
سنة النشر:
2007
مصطلحات موضوعية:
Stereochemistry , Receptor, Metabotropic Glutamate 5 , Clinical Biochemistry , Pharmaceutical Science , CHO Cells , Class iii , Receptors, Metabotropic Glutamate , Biochemistry , Chemical synthesis , Structure-Activity Relationship , chemistry.chemical_compound , Cricetulus , In vivo , Cricetinae , Drug Discovery , Animals , Naphthyridines , Receptor , Molecular Biology , G protein-coupled receptor , Aryl , Organic Chemistry , Stereoisomerism , In vitro , Rats , Metabotropic receptor , chemistry , Molecular Medicine
الوصف:
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
تدمد:
0960-894X
DOI:
10.1016/j.bmcl.2007.09.083
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99bb1ead705ce7ec70a6e5c13920183 https://doi.org/10.1016/j.bmcl.2007.09.083
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....d99bb1ead705ce7ec70a6e5c13920183
قاعدة البيانات:
OpenAIRE