Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng
| العنوان: | Anticancer Effect of Mountain Ginseng on Human Breast Cancer: Comparison with Farm-Cultivated Ginseng |
|---|---|
| المؤلفون: | Hyo Jung Kim, Jin-Soo Kim, Sun-Gun Kim, Young Mi Seok, Jae-Myung Yoo, Jungeun Kim, Jong Eel Park, Jun-Ho Son |
| المصدر: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) |
| بيانات النشر: | Hindawi, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0303 health sciences, Article Subject, Cytochrome c, Cancer, Pharmacology, Biology, medicine.disease, In vitro, 03 medical and health sciences, chemistry.chemical_compound, Ginseng, Other systems of medicine, 0302 clinical medicine, Complementary and alternative medicine, chemistry, In vivo, Ginsenoside, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, medicine, Cytotoxicity, RZ201-999, 030304 developmental biology, Research Article |
| الوصف: | Mountain ginseng has been used generally as a pharmacopuncture for cancer therapy in clinical practice in Northeast Asia. Nonetheless, there have been few scientific reports for the anticancer action of mountain ginseng. In this study, we investigated whether mountain ginseng extract (MGE) could inhibit the growth of breast cancer in in vitro and in vivo models. MGE showed stronger cytotoxicity than farm-cultivated ginseng extract (FGE) through promoting ROS generation. Also MGE dose-dependently brought about mitochondrial dysfunction in MCF-7 cells. In addition, MGE induced apoptosis through enhancing the activities of caspase-3/7 by regulation of expression of Bcl-2, Bax, cytochrome c, and cleaved caspase-3 in the MCF-7 cells. Consistent with the in vitro results, MGE significantly reduced tumor weights compared with FGE in mice transplanted with MCF-7 cells, and it regulated the expression of apoptosis-related proteins, such as Bcl-2, Bax, cytochrome c, cleaved caspase-3, and cleaved PARP, in the tumor tissues. Additionally, MGE included higher total ginsenoside contents than FGE. In conclusion, MGE, which is richer in ginsenosides, exerts a stronger anticancer action than FGE in breast cancer. The anticancer action of MGE may be closely correlated with caspase-mediated apoptosis through upregulating ROS generation. Therefore, these findings may be helpful for a clinical understanding of the anticancer mechanism of MGE for breast cancer patients. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1741-4288 1741-427X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9045a2a574d0c6c7baf8702dd0235b8 http://europepmc.org/articles/PMC7399781 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9045a2a574d0c6c7baf8702dd0235b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
|---|