Interleukin‐35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
| العنوان: | Interleukin‐35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis |
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| المؤلفون: | Paola Carvajal, Nicolás González, Cristian Covarrubias, Rolando Vernal, Claudia Terraza-Aguirre, Marcela Hernández, Nicolás Faúndez, Emilio A Cafferata, Cristian Cortez, Samanta Melgar-Rodríguez, Fermín E. González, Romina Barrera, Carolina Rojas |
| المصدر: | Journal of Clinical Periodontology. 47:676-688 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Th17 treg, Alveolar Bone Loss, T-Lymphocytes, Regulatory, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, 030212 general & internal medicine, Periodontitis, Dental alveolus, biology, business.industry, Interleukins, X-Ray Microtomography, 030206 dentistry, medicine.disease, Resorption, RANKL, Immunology, Interleukin 35, biology.protein, Th17 Cells, Periodontics, business |
| الوصف: | T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting alveolar bone resorption. Interleukin (IL)-35 is a novel anti-inflammatory cytokine with therapeutic properties in diseases whose pathogenesis is associated with the Th17/Treg imbalance; however, its role during periodontitis has not been established yet. This study aimed to elucidate whether IL-35 inhibits the alveolar bone resorption during periodontitis by modulating the Th17/Treg imbalance.Mice with ligature-induced periodontitis were treated with locally or systemically administrated IL-35. As controls, periodontitis-affected mice without IL-35 treatment and non-ligated mice were used. Alveolar bone resorption was measured by micro-computed tomography and scanning electron microscopy. The Th17/Treg pattern of the immune response was analysed by qPCR, ELISA, and flow cytometry.IL-35 inhibited alveolar bone resorption in periodontitis mice. Besides, IL-35 induced less detection of Th17 lymphocytes and production of Th17-related cytokines, together with higher detection of Treg lymphocytes and production of Treg-related cytokines in periodontitis-affected tissues.IL-35 is beneficial in the regulation of periodontitis; particularly, IL-35 inhibited alveolar bone resorption and this inhibition was closely associated with modulation of the periodontal Th17/Treg imbalance. |
| تدمد: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.13282 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fb4ed19daf8e32ea1025e24b90ec72 https://doi.org/10.1111/jcpe.13282 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d8fb4ed19daf8e32ea1025e24b90ec72 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1600051X 03036979 |
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| DOI: | 10.1111/jcpe.13282 |