Radiolabelled cytokines for imaging chronic inflammation
| العنوان: | Radiolabelled cytokines for imaging chronic inflammation |
|---|---|
| المؤلفون: | Francesco Scopinaro, Alessio Annovazzi, Alberto Signore, Calogero D'Alessandria |
| المصدر: | Brazilian Archives of Biology and Technology, Volume: 45, Issue: spe, Pages: 15-23, Published: SEP 2002 Brazilian Archives of Biology and Technology, Vol 45, Iss spe, Pp 15-23 (2002) Brazilian Archives of Biology and Technology v.45 n.spe 2002 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
| بيانات النشر: | Instituto de Tecnologia do Paraná - Tecpar, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | chronic inflammation, Multidisciplinary, business.industry, lcsh:Biotechnology, imaging, Inflammation, Chronic disorders, Clinical Practice, lcsh:TP248.13-248.65, Immunology, Medicine, Radiolabelled cytokines, medicine.symptom, business |
| الوصف: | Diagnosis and particularly follow-up of chronic inflammatory disorders could be often difficult in clinical practice. Indeed, traditional radiological techniques reveal only structural tissue alterations and are not able to monitor functional changes occurring in tissues affected by chronic inflammation. The continuous advances in the knowledge of the pathophysioloy of chronic disorders, combined with the progress of radiochemistry, led to the development of new specific radiolabelled agents for the imaging of chronic diseases. In this scenario, cytokines, due to their pivotal role in such diseases, represent good candidates as radiopharmaceuticals.O diagnóstico, e particularmente o acompanhamento das doenças inflamatórias crônicas, pode ser freqüentemente muito difícil na prática clínica. As técnicas radiológicas tradicionais revelam somente as alterações teciduais estruturas, não sendo capazes de monitorar as alterações funcionais que ocorrem nesses tecidos afetados pela inflamação crônica. O contínuo avanço no conhecimento da fisiopatologia dessas doenças, combinado com o progresso da radioquímica, levou ao desenvolvimento de novos agentes radiomarcados para a obtenção de imagens de doenças crônicas. Nesse cenário, as citocinas, devido ao papel primordial em tais doenças, apresentam-se como fortes candidatas a radiofármacos. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89114a3b28ac84a0c2711e7e49fd732 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500004&lng=en&tlng=en |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d89114a3b28ac84a0c2711e7e49fd732 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |