Lyme borreliosis: diagnosis and management
| العنوان: | Lyme borreliosis: diagnosis and management |
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| المؤلفون: | Bart Jan Kullberg, Hedwig D. Vrijmoeth, Joppe W. Hovius, Freek R. van de Schoor |
| المساهمون: | Center of Experimental and Molecular Medicine, Infectious diseases, AII - Infectious diseases |
| المصدر: | Bmj. British Medical Journal (Compact Ed.), 369 BMJ (Clinical research ed.), 369:m1041. British Medical Association |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.drug_class, Antibiotics, Arthritis, Disease, Serology, 03 medical and health sciences, 0302 clinical medicine, Lyme disease, Borrelia burgdorferi Group, medicine, Prevalence, Humans, 030212 general & internal medicine, 0303 health sciences, Lyme Disease, Post-Lyme Disease Syndrome, 030306 microbiology, business.industry, Acrodermatitis, General Medicine, medicine.disease, Dermatology, Pathophysiology, Anti-Bacterial Agents, Europe, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], North America, Erythema migrans, Erythema Chronicum Migrans, Female, business, Acrodermatitis chronica atrophicans |
| الوصف: | Contains fulltext : 220683.pdf (Publisher’s version ) (Closed access) Lyme borreliosis is the most common vectorborne disease in the northern hemisphere. It usually begins with erythema migrans; early disseminated infection particularly causes multiple erythema migrans or neurologic disease, and late manifestations predominantly include arthritis in North America, and acrodermatitis chronica atrophicans (ACA) in Europe. Diagnosis of Lyme borreliosis is based on characteristic clinical signs and symptoms, complemented by serological confirmation of infection once an antibody response has been mounted. Manifestations usually respond to appropriate antibiotic regimens, but the disease can be followed by sequelae, such as immune arthritis or residual damage to affected tissues. A subset of individuals reports persistent symptoms, including fatigue, pain, arthralgia, and neurocognitive symptoms, which in some people are severe enough to fulfil the criteria for post-treatment Lyme disease syndrome. The reported prevalence of such persistent symptoms following antimicrobial treatment varies considerably, and its pathophysiology is unclear. Persistent active infection in humans has not been identified as a cause of this syndrome, and randomized treatment trials have invariably failed to show any benefit of prolonged antibiotic treatment. For prevention of Lyme borreliosis, post-exposure prophylaxis may be indicated in specific cases, and novel vaccine strategies are under development. |
| وصف الملف: | application/pdf |
| تدمد: | 1756-1833 0959-8146 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86aecffc848b35f088a7f1234ae1910 http://hdl.handle.net/2066/220683 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d86aecffc848b35f088a7f1234ae1910 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17561833 09598146 |
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