Effect of niacin monotherapy on high density lipoprotein composition and function
| العنوان: | Effect of niacin monotherapy on high density lipoprotein composition and function |
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| المؤلفون: | Marcelo Amar, Michael Stagliano, Emma Staller, Nehal N. Mehta, Kianoush Jeiran, Alan T. Remaley, Martin P. Playford, Tomas Vaisar, Scott M. Gordon |
| المصدر: | Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-10 (2020) Lipids in Health and Disease |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Proteomics, Apolipoprotein B, Apolipoprotein L1, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, High density lipoprotein, 030204 cardiovascular system & hematology, Mass Spectrometry, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, High-density lipoprotein, Cholesterol efflux, lcsh:RC620-627, Serum amyloid a, biology, digestive, oral, and skin physiology, food and beverages, Middle Aged, lcsh:Nutritional diseases. Deficiency diseases, Cholesterol, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Niacin, Lipidology, Adult, Niacinamide, medicine.medical_specialty, Clinical chemistry, 030209 endocrinology & metabolism, 03 medical and health sciences, Internal medicine, medicine, Humans, Triglyceride, business.industry, Research, Biochemistry (medical), Cholesterol, HDL, nutritional and metabolic diseases, Vitamin B3, Apolipoproteins, chemistry, biology.protein, business |
| الوصف: | Background Niacin has modest but overall favorable effects on plasma lipids by increasing high density lipoprotein cholesterol (HDL-C) and lowering triglycerides. Clinical trials, however, evaluating niacin therapy for prevention of cardiovascular outcomes have returned mixed results. Recent evidence suggests that the HDL proteome may be a better indicator of HDL’s cardioprotective function than HDL-C. The objective of this study was to evaluate the effect of niacin monotherapy on HDL protein composition and function. Methods A 20-week investigational study was performed with 11 participants receiving extended-release niacin (target dose = 2 g/day) for 16-weeks followed by a 4-week washout period. HDL was isolated from participants at weeks: 0, 16, and 20. The HDL proteome was analyzed at each time point by mass spectrometry and relative protein quantification was performed by label-free precursor ion intensity measurement. Results In this cohort, niacin therapy had typical effects on routine clinical lipids (HDL-C + 16%, q Conclusion Extended-release niacin therapy, in the absence of other lipid-modifying medications, can increase HDL-associated SAA, an acute phase protein associated with HDL dysfunction. |
| اللغة: | English |
| DOI: | 10.1186/s12944-020-01350-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d841078626008bfd747ac419fc2c3341 http://link.springer.com/article/10.1186/s12944-020-01350-3 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d841078626008bfd747ac419fc2c3341 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1186/s12944-020-01350-3 |
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