Analysing the trend over time of antibiotic consumption in the community : a tutorial on the detection of common change-points
| العنوان: | Analysing the trend over time of antibiotic consumption in the community : a tutorial on the detection of common change-points |
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| المؤلفون: | Rolanda Valintėlienė, Berit Müller-Pebody, Anna Olczak-Pieńkowska, Reinhild Strauss, Marina Payerl-Pal, Niels Adriaenssens, Tomáš Tesař, Hege Salvesen Blix, Gabriel Adrian Popescu, Emmi Sarvikivi, Stefana Sabtcheva, Robin Bruyndonckx, Jiří Vlček, Gudrun Aspelund, Stephanie Natsch, Andis Seilis, Herman Goossens, Mária Matuz, Isavella Kyriakidou, Niel Hens, Elviira Linask, Ann Versporten, Philippe Cavalié, Filomena Fortinguerra, Dominique L Monnet, Peter Zarb, Tim Eckmanns, Milan Čižman, Ana Silva, Marcel Bruch, Samuel Coenen, Eline Vandael, Antonio López Navas, Geert Molenberghs, Flora Kontopidou, Ute Wolff Sönksen, Vendela Bergfeldt, K. Burns, Klaus Weist |
| المساهمون: | ESAC-Net Study Group |
| المصدر: | The journal of antimicrobial chemotherapy Journal of Antimicrobial Chemotherapy Journal of Antimicrobial Chemotherapy, 76, ii79-ii85 Journal of Antimicrobial Chemotherapy, 76, 12 Suppl 2, pp. ii79-ii85 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Mixed model, Index (economics), Computer science, 030106 microbiology, 03 medical and health sciences, 0302 clinical medicine, Statistics, AcademicSubjects/MED00740, Humans, Pharmacology (medical), 030212 general & internal medicine, skin and connective tissue diseases, Biology, Pharmacology, Consumption (economics), Time trends, Pharmacology. Therapy, Drug Utilization, Anti-Bacterial Agents, Europe, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, AcademicSubjects/MED00290, Supplement Papers, Change points, sense organs, Human medicine, AcademicSubjects/MED00230 |
| الوصف: | Objectives This tutorial describes and illustrates statistical methods to detect time trends possibly including abrupt changes (referred to as change-points) in the consumption of antibiotics in the community. Methods For the period 1997–2017, data on consumption of antibacterials for systemic use (ATC group J01) in the community, aggregated at the level of the active substance, were collected using the WHO ATC/DDD methodology and expressed in DDD (ATC/DDD index 2019) per 1000 inhabitants per day. Trends over time and presence of common change-points were studied through a set of non-linear mixed models. Results After a thorough description of the set of models used to assess the time trend and presence of common change-points herein, the methodology was applied to the consumption of antibacterials for systemic use (ATC J01) in 25 EU/European Economic Area (EEA) countries. The best fit was obtained for a model including two change-points: one in the first quarter of 2004 and one in the last quarter of 2008. Conclusions Allowing for the inclusion of common change-points improved model fit. Individual countries investigating changes in their antibiotic consumption pattern can use this tutorial to analyse their country data. |
| وصف الملف: | Print; application/pdf |
| اللغة: | English |
| تدمد: | 0305-7453 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cdef53e0597d1dfd7268c11a68d635 https://hdl.handle.net/10067/1795480151162165141 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7cdef53e0597d1dfd7268c11a68d635 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03057453 |
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