Aetiological heterogeneity of head and neck squamous cell carcinomas: the role of human papillomavirus infections, smoking and alcohol
| العنوان: | Aetiological heterogeneity of head and neck squamous cell carcinomas: the role of human papillomavirus infections, smoking and alcohol |
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| المؤلفون: | Sreenath Arekunnath Madathil, Marie-Claude Rousseau, François Coutlée, Belinda Nicolau, Eduardo L. Franco, Geneviève Castonguay, Paul J. Allison, Phuc Felix Nguyen-Tan, Nicolas F. Schlecht, Denis Soulières, Nada Farsi, Micheal Hier |
| المساهمون: | King Abdulaziz University, McGill University = Université McGill [Montréal, Canada], Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Albert Einstein College of Medicine [New York], Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), BN holds a Canada Research Chair in life course oral epidemiology. MCR was a recipient of a Career Award from the Fonds de recherche du Québec – Santé (FRQS). NJF was a scholarship recipient from the Saudi Cultural Bureau in Canada. This study was funded by CIHR grant numbers: MOP-69062, MOP-201009, DCA-122700 and the Ministère du Développement économique, de l’Innovation et de l’Exportation du Québec., Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS) |
| المصدر: | Carcinogenesis Carcinogenesis, Oxford University Press (OUP), 2017, 38 (12), pp.1188-1195. ⟨10.1093/carcin/bgx106⟩ |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Oncology, Cancer Research, [SDV]Life Sciences [q-bio], MESH: Papillomavirus Infections, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Odds Ratio, 030212 general & internal medicine, MESH: Aged, MESH: Middle Aged, Smoking, HPV infection, MESH: Carcinoma, Squamous Cell, General Medicine, Middle Aged, MESH: Case-Control Studies, 3. Good health, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Adult, MESH: Smoking, medicine.medical_specialty, Alcohol Drinking, 03 medical and health sciences, Internal medicine, medicine, Carcinoma, Humans, Aged, MESH: Humans, Squamous Cell Carcinoma of Head and Neck, business.industry, Papillomavirus Infections, Head and neck cancer, Case-control study, Cancer, MESH: Adult, Odds ratio, medicine.disease, Head and neck squamous-cell carcinoma, MESH: Odds Ratio, MESH: Male, Confidence interval, MESH: Head and Neck Neoplasms, stomatognathic diseases, Case-Control Studies, business, MESH: Female, MESH: Alcohol Drinking |
| الوصف: | International audience; Tobacco and alcohol consumption are the main risk factors for head and neck squamous cell carcinoma (HNSCC). In addition, human papillomavirus (HPV) infection plays a causal role in oropharyngeal cancer (OPC), a subset of HNSCC. We assessed the independent effects of tobacco, alcohol and HPV infection on OPC risk in the head and neck cancer (HeNCe) Life study, a hospital-based case-control study of HNSCC with frequency-matched controls by age and sex from four Montreal hospitals. Interviewers collected information on socio-demographic and behavioural factors. We tested exfoliated oral cells for HPV DNA by polymerase chain reaction (PCR). We included only OPC cases (n = 188) and controls (n = 427) without missing values for HPV, smoking or alcohol. We examined associations by estimating odds ratios (ORs) and corresponding 95% confidence intervals (CI) using unconditional logistic regression. Smoking (OR = 1.90, 95% CI: 1.04-3.45) and alcohol (OR = 2.74, 95% CI: 1.45-5.15) were associated with an increased risk of OPC independent of HPV status. Positivity for HPV 16 among heavy smokers and heavy alcohol users was associated with a 30.4-fold (95% CI: 8.94-103.26) and 18.6-fold (95% CI: 5.75-60.13) elevation in risk of OPC relative to participants who were HPV negative, respectively. Moreover, the combined effect of heavy smoking and alcohol comsumption with HPV 16 infection substantially increased OPC risk (OR = 48.76, 95% CI: 15.83-150.17) and (OR = 50.60, 95% CI: 15.96-160.40), respectively. Our results support the independent roles of smoking, alcohol and HPV infection in OPC risk and a possible combined effect. Efforts should be made to tackle these major risk factors simultaneously. |
| تدمد: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/bgx106 |
| DOI: | 10.1093/carcin/bgx106⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c8ddeb8b0367eb4de4537bc88c86ef https://doi.org/10.1093/carcin/bgx106 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7c8ddeb8b0367eb4de4537bc88c86ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602180 01433334 |
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| DOI: | 10.1093/carcin/bgx106 |