Data Quality Challenges in Systemic Lupus Erythematosus Trials: How Can This Be Optimized?
| العنوان: | Data Quality Challenges in Systemic Lupus Erythematosus Trials: How Can This Be Optimized? |
|---|---|
| المؤلفون: | Marilyn C. Pike, Lexy Kelley |
| المصدر: | Current Rheumatology Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | medicine.medical_specialty, SLE, New agents, MEDLINE, Severity of Illness Index, Inflammatory bowel disease, Systemic Lupus Erythematosus (Jt Merrill, Section Editor), Systemic lupus erythematosus, Optimize, Rheumatology, Internal medicine, medicine, Humans, Immunologic Factors, Lupus Erythematosus, Systemic, Molecular Targeted Therapy, Challenge, Intensive care medicine, Trials, Clinical Trials as Topic, Lupus erythematosus, business.industry, Multiple sclerosis, Data quality, Central adjudication committees, Translational medicine, medicine.disease, Research Design, Rheumatoid arthritis, Immunology, Therapy, Disease Activity Index, business |
| الوصف: | Major scientific advances in basic science, pharmacology, and translational medicine have allowed the discovery of new molecular targets whose manipulation by new chemical entities has led to treatments for inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Development of new agents for systemic lupus erythematosus (SLE) has lagged, however, because the protean manifestations of SLE present challenges for measuring therapeutic effects in a consistent manner. Composite end points combining several Disease Activity Indices (DAIs) are being used in ongoing global studies, but the uniform application of these complex DAIs across large numbers of clinical sites has proven difficult. We describe herein approaches that are being utilized to facilitate collection, review, and analysis of the clinical measures utilizing independent central adjudication committees. |
| تدمد: | 1534-6307 1523-3774 |
| DOI: | 10.1007/s11926-012-0261-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ab992e41bdd6a7641d906088fefc50 https://doi.org/10.1007/s11926-012-0261-7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7ab992e41bdd6a7641d906088fefc50 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15346307 15233774 |
|---|---|
| DOI: | 10.1007/s11926-012-0261-7 |