Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation
| العنوان: | Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation |
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| المؤلفون: | Aaron M. Robitaille, Robert E. Stanley, Xiao Yong Yang, Benjamin N.R. Cheyette, Adam P. Ross, John A. Gray |
| المصدر: | Cerebral cortex (New York, N.Y. : 1991), vol 29, iss 3 Yang, XY; Stanley, RE; Ross, AP; Robitaille, AM; Gray, JA; & Cheyette, BNR. (2018). Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.. Cerebral cortex (New York, N.Y. : 1991). doi: 10.1093/cercor/bhy026. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7711j2xp Cerebral cortex (New York, N.Y. : 1991), vol 29, iss 2 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, rac1 GTP-Binding Protein, RHOA, hippocampus, GTPase, Inbred C57BL, Transgenic, Synapse, Mice, 0302 clinical medicine, Postsynaptic potential, Psychology, Mice, Knockout, biology, Chemistry, breakpoint cluster region, Experimental Psychology, Cell biology, medicine.anatomical_structure, Cerebral cortex, Neurological, Proto-Oncogene Proteins c-bcr, Excitatory postsynaptic potential, Female, Cognitive Sciences, Guanine nucleotide exchange factor, Corrigendum, Knockout, Intellectual and Developmental Disabilities (IDD), 1.1 Normal biological development and functioning, Dendritic Spines, Neurogenesis, Cognitive Neuroscience, projection, glutamate, Mice, Transgenic, RAC1, Dendrite, 03 medical and health sciences, Cellular and Molecular Neuroscience, Organ Culture Techniques, Prosencephalon, medicine, Animals, Synapse formation, pyramidal, Neuropeptides, Neurosciences, Original Articles, Dendrites, Brain Disorders, Mice, Inbred C57BL, Spine (zoology), 030104 developmental biology, nervous system, Synapses, Forebrain, biology.protein, Carrier Proteins, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | SEC14 and Spectrin domain-1 (Sestd1) is a synapse protein that exhibits a striking shift from the presynaptic to postsynaptic space as neurons mature postnatally in the mouse hippocampus. Hippocampal pyramidal neurons from mice with global genetic deletion of Sestd1 have reduced dendrite arbors, spines, and excitatory synapses. Electrophysiologically this correlates with cell-autonomous reductions in both AMPA- and NMDA-excitatory postsynaptic currents in individual hippocampal neurons from which Sestd1 has been deleted in vivo. These neurodevelopmental and functional deficits are associated with increased activation of the Rho family GTPases Rac1 and RhoA. Co-immunoprecipitation and mass spectrometry reveal that the Breakpoint Cluster Region protein, a Rho GTPase activating protein (GAP), forms complexes with Sestd1 in brain tissue. This complements earlier findings that Sestd1 can also partner with other Rho family GAPs and guanine nucleotide exchange factors. Our findings demonstrate that Sestd1 is a developmentally dynamic synaptic regulator of Rho GTPases that contributes to dendrite and excitatory synapse formation within differentiating pyramidal neurons of the forebrain. |
| وصف الملف: | application/pdf |
| تدمد: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhy026 |
| DOI: | 10.1093/cercor/bhy026. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d771bdc96211488627def04903c7f5e4 https://doi.org/10.1093/cercor/bhy026 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d771bdc96211488627def04903c7f5e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602199 10473211 |
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| DOI: | 10.1093/cercor/bhy026 |