Skull diploë is rich in aquaporin-4
| العنوان: | Skull diploë is rich in aquaporin-4 |
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| المؤلفون: | Tsutomu Nakada, Akiyoshi Kakita, Nicholas Capozzoli, Ingrid L. Kwee, Yuji Suzuki, Yukimi Nakamura, Hiroki Kitaura, Vincent J. Huber |
| المصدر: | Heliyon, Vol 6, Iss 1, Pp e03259-(2020) Heliyon |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Aquaporin, Aquaporin 4 (AQP4), Article, Immunohistology, 03 medical and health sciences, 0302 clinical medicine, N-(1,3,4-thiadiazol-2-yl) pyridine-3-[11C]-carboxamide ([11C]TGN-020), medicine, Radioligand, lcsh:Social sciences (General), Bone, lcsh:Science (General), Integral membrane protein, Multidisciplinary, medicine.diagnostic_test, Chemistry, Skull, Imaging agent, Tissue culture, 030104 developmental biology, medicine.anatomical_structure, Aquaporin 4, Positron emission tomography, Nuclear medicine, lcsh:H1-99, sense organs, Medical imaging, Anatomy, Radiology, Positron emission tomography(PET), 030217 neurology & neurosurgery, Astrocyte, lcsh:Q1-390 |
| الوصف: | Aquaporin-4 (AQP4) is a water conducting membrane integral protein channel which is widely expressed in the astrocyte system of the brain. During the development of the AQP4 positron emission tomography (PET) imaging agent [11C]TGN-020 (N-(1,3,4-thiadiazol-2-yl)pyridine-3-[11C]-carboxamide), significant radioligand uptake was observed in the skull, where there was no known distribution of any aquaporin family proteins. Herein we confirmed via a newly developed method for bone-tissue immunohistology, a hitherto unrecognized distribution of AQP4, and not AQP1, in the skull. Other bony structures, by contrast, showed virtually no uptake of [11C]TGN-020, and likewise, do not express either AQP4 or AQP1. Immunohistological analysis demonstrated that the AQP4 expression in the skull is restricted to the diploë. Consequently, we suspect AQP4 plays a pivotal role in the formation and maintenance of yellow marrow and the diploë. However, elucidating the exact nature of that role will require further studies. Anatomy; Pathology; Medical imaging; Nuclear medicine; Radiology; Tissue culture; Bone; Aquaporin 4 (AQP4); Skull; Positron emission tomography(PET); N-(1,3,4-thiadiazol-2-yl) pyridine-3-[11C]-carboxamide ([11C]TGN-020); Immunohistology. |
| اللغة: | English |
| تدمد: | 2405-8440 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3ad8af4595ac426caa405c2d9cae4 http://www.sciencedirect.com/science/article/pii/S2405844020301043 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d6e3ad8af4595ac426caa405c2d9cae4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24058440 |
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