Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease?
| العنوان: | Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease? |
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| المؤلفون: | Allan Lawrie, Luke Howard, Gerry Coghlan, Martin R. Wilkins, Nicholas W. Morrell, David G. Kiely, Martin Johnson, Eleni Sofianopoulou, SJ Wort, Mark Toshner, James L. Lordan, Colin Church |
| المساهمون: | Toshner, Mark [0000-0002-3969-6143], Morrell, Nicholas [0000-0001-5700-9792], Apollo - University of Cambridge Repository |
| المصدر: | The European Respiratory Journal article-version (VoR) Version of Record |
| بيانات النشر: | European Respiratory Society (ERS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Hypertension, Pulmonary, education, Respiratory System, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Rare Diseases, Internal medicine, polycyclic compounds, medicine, Health Status Indicators, Humans, In patient, Familial Primary Pulmonary Hypertension, 030212 general & internal medicine, Agora, 11 Medical and Health Sciences, Aged, Proportional Hazards Models, Retrospective Studies, Pulmonary Arterial Hypertension, business.industry, Middle Aged, Prognosis, humanities, Research Letters, 030228 respiratory system, Social Isolation, Scotland, Risk stratification, Female, business, Rare disease |
| الوصف: | In this journal, Pellino et al. [1] presented a survival analysis to assess how deprivation affects prognosis in patients with pulmonary arterial hypertension (PAH). Their conclusions were that social deprivation is not a significant referral barrier or prognostic factor for idiopathic (I)PAH or heritable (H)PAH in Scotland. This may appear surprising, given the wider context of literature describing outcomes stratified by social deprivation. The authors were thorough on using both the address at time of diagnosis and at time of censoring to assign deprivation scores and compare the two, finding no significant differences between the two approaches. They also compared deprivation assigned to PAH cases to expected deprivation based on Scottish citizenry as a whole, and found that PAH patients are more socially deprived than expected. Finally, they used the same survival univariate analysis adjusting for age and sex to assess how several clinical variables are associated with prognosis. No association was found between deprivation and mortality for PAH patients in England and Wales. The association found between risk stratification at baseline and deprivation suggests that the issue of deprivation and outcomes in PAH may be more nuanced. https://bit.ly/2y8WgqB |
| وصف الملف: | application/pdf; application/octet-stream; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| تدمد: | 0903-1936 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63ef6ffea062c92ff9b7eadec457063 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d63ef6ffea062c92ff9b7eadec457063 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09031936 |
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