Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis
| العنوان: | Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis |
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| المؤلفون: | Sobral-Leite, M., Wesseling, J., Smit, V.T., Nevanlinna, H., Miltenburg, M.H. van, Sanders, J., Hofland, I., Blows, F.M., Coulson, P., Patrycja, G., Schellens, J.H., Fagerholm, R., Heikkilä, P., Aittomäki, K., Blomqvist, C., Provenzano, E., Ali, H.R., Figueroa, J., Sherman, M., Lissowska, J., Mannermaa, A., Kataja, V., Kosma, V.M., Hartikainen, J.M., Phillips, K.A., Couch, F.J., Olson, J.E., Vachon, C., Visscher, D., Brenner, H., Butterbach, K., Arndt, V., Holleczek, B., Hooning, M.J., Hollestelle, A., Martens, J.W., Deurzen, C.H. van, Water, B. van de, Broeks, A., Chang-Claude, J., Chenevix-Trench, G., Easton, D.F., Pharoah, P.D., García-Closas, M., Graauw, M. de, Schmidt, M.K. |
| المساهمون: | Apollo - University of Cambridge Repository, Medical Oncology, Pathology |
| المصدر: | BMC Medicine, 13. BioMed Central Ltd. BMC Medicine BMC Medicine, 13, 156 |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Medicine(all), endocrine system, Genes, BRCA2, Genes, BRCA1, Breast Neoplasms, Middle Aged, Prognosis, Immunohistochemistry, BRCA1 and BRCA2 mutations, Breast cancer, SDG 3 - Good Health and Well-being, Mutation, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, skin and connective tissue diseases, Annexin A1, Research Article |
| الوصف: | Background Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 1741-7015 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63b9ee36942202ef3067b80b3e16662 https://hdl.handle.net/1887/51532 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d63b9ee36942202ef3067b80b3e16662 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417015 |
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