Role of adenosine in the treatment of myocardial stunning
| العنوان: | Role of adenosine in the treatment of myocardial stunning |
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| المؤلفون: | Mervyn B. Forman, Carlos E. Velasco |
| المصدر: | Cardiovascular Drugs and Therapy. 5:901-908 |
| بيانات النشر: | Springer Science and Business Media LLC, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | medicine.medical_specialty, Adenosine, Ischemia, Coronary Disease, Pharmacology, chemistry.chemical_compound, Adenosine Triphosphate, Oxygen Consumption, Postoperative Complications, Coronary Circulation, Internal medicine, medicine, Animals, Humans, Pharmacology (medical), Calcium metabolism, Myocardial stunning, business.industry, Stunning, General Medicine, medicine.disease, Adenosine receptor, Endocrinology, chemistry, Calcium, Cardiology and Cardiovascular Medicine, business, Adenosine triphosphate, Nucleoside, medicine.drug |
| الوصف: | Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved. |
| تدمد: | 1573-7241 0920-3206 |
| DOI: | 10.1007/bf00053551 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c161c034b9053e7f8e038e9ef1d898 https://doi.org/10.1007/bf00053551 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d5c161c034b9053e7f8e038e9ef1d898 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737241 09203206 |
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| DOI: | 10.1007/bf00053551 |