A multiscale model for the simulation of cerebral and extracerebral blood flows and pressures in humans
| العنوان: | A multiscale model for the simulation of cerebral and extracerebral blood flows and pressures in humans |
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| المؤلفون: | Piotr Zieliński, Angelo Taibi, Mauro Gambaccini, Marcin Majka, Giacomo Gadda |
| المصدر: | European Journal of Applied Physiology. 118:2443-2454 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Computer science, Socio-culturale, Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, Breathing, Cerebral and extracerebral parameters, Circulation, CO2pressure change, Mathematical modeling, 03 medical and health sciences, Cerebral circulation, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Humans, Computer Simulation, Orthopedics and Sports Medicine, Autoregulation, Models, Cardiovascular, Public Health, Environmental and Occupational Health, Arteries, General Medicine, Arterial tree, Transmission properties, Cerebrovascular Circulation, Cardiology, Blood supply, medicine.symptom, Hypercapnia, 030217 neurology & neurosurgery |
| الوصف: | Brain hemodynamics is fundamental for the functioning of the human being. Many biophysical factors affect brain circulation, so that a satisfactory understanding of its behavior is challenging. We developed a mathematical model to simulate cerebral and extracerebral flows and pressures in humans. The model is composed of an anatomically informed 1-D arterial network, and two 0-D networks of the cerebral circulation and brain drainage, respectively. It takes into account the pulse-wave transmission properties of the 55 main arteries and the main hydraulic and autoregulation mechanisms ensuring blood supply and drainage to the brain. Proper pressure outputs from the arterial 1-D model are used as input to the 0-D models, together with the contribution to venous pressure due to breathing that simulates the drainage effect of the thoracic pump. The model we developed is able to link the arterial tree with the venous pathways devoted to the brain drainage, and to simulate important factors affecting cerebral circulation both for physiological and pathological conditions, such as breathing and hypo/hypercapnia. Finally, the average value of simulated flows and pressures is in agreement with the available experimental data. The model has the potential to predict important clinical parameters before and after physiological and/or pathological changes. |
| تدمد: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-018-3971-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b377b64404ca9778beef46e57b0cfc https://doi.org/10.1007/s00421-018-3971-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d5b377b64404ca9778beef46e57b0cfc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14396327 14396319 |
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| DOI: | 10.1007/s00421-018-3971-3 |