Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
| العنوان: | Gene-by-environment modulation of lifespan and weight gain in the murine BXD family |
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| المؤلفون: | Maroun Bou Sleiman, Lu Lu, Melinda S McCarty, Thomas M. Shapaker, Liza Makowski, Robert W Read, Anna Sun, Saunak Sen, Michael Hook, Wenyuan Zhao, Arthur G. Centeno, Lynda A. Wilmott, Catherine C. Kaczorowski, Sarah M. Neuner, Khyobeni Mozhui, Jesse D. Ziebarth, Megan K. Mulligan, Richard A. Miller, David G. Ashbrook, Evan G. Williams, Casey J Chapman, Suheeta Roy, Pooja Jha, Johan Auwerx, Jesse Ingels, Jinsong Huang, Yan Cui, Robert W. Williams |
| بيانات النشر: | NATURE PORTFOLIO |
| مصطلحات موضوعية: | obesity, systems genetics, mice, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Physiology, Biology, Body weight, Diet, High-Fat, Weight Gain, adipose-tissue, insulin-resistance, model organisms, Cohort Studies, longevity, Physiology (medical), fat, Genetic variation, Internal Medicine, medicine, Animals, mouse, media_common, Gene by environment, Body Weight, Longevity, dietary restriction, Cell Biology, Chow diet, Mice, Inbred C57BL, Cohort, Gene-Environment Interaction, medicine.symptom, Weight gain |
| الوصف: | How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a low-fat chow diet (CD, n = 663) or a high-fat diet (HFD, n = 685). We further generate key metabolic data in a parallel cohort euthanized at four time points. HFD feeding shortens lifespan by 12%: equivalent to a decade in humans. Initial body weight and early weight gains account for longevity differences of roughly 4-6 days per gram. At 500 days, animals on a HFD typically gain four times as much weight as control, but variation in weight gain does not correlate with lifespan. Classic serum metabolites, often regarded as health biomarkers, are not necessarily strong predictors of longevity. Our data indicate that responses to a HFD are substantially modulated by gene-by-environment interactions, highlighting the importance of genetic variation in making accurate individualized dietary recommendations. Roy et al. quantify the impact of a high-fat diet across genetically diverse strains of mice, revealing a generally negative effect on lifespan but also a wide variability. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e1cea5f9fe725c9807eaf51d7a5b6 https://infoscience.epfl.ch/record/289234 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d51e1cea5f9fe725c9807eaf51d7a5b6 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |