التفاصيل البيبلوغرافية
| العنوان: |
External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients |
| المؤلفون: |
Christoph Würnschimmel, Zhe Tian, Alberto Briganti, Pierre I. Karakiewicz, Carlo Terrone, Francesco Chierigo, Felix K.-H. Chun, Rocco Simone Flammia, Derya Tilki, Mike Wenzel, Markus Graefen, Shahrokh F. Shariat, M. Gallucci, Fred Saad, Nazareno Suardi |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
African american, medicine.medical_specialty, Prostatectomy, business.industry, Urology, medicine.medical_treatment, Hazard ratio, Cancer, cancer-specific mortality, epidemiology and end results, external beam radiotherapy, localized prostate cancer, other-cause mortality, radical prostatectomy, surveillance, medicine.disease, Prostate cancer, Epidemiology, Propensity score matching, medicine, External beam radiotherapy, ddc:610, business |
| الوصف: |
Objectives To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients. Methods In the Surveillance, Epidemiology and End Results database 2004-2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with external beam radiotherapy or radical prostatectomy. Race/ethnicity-stratified cancer-specific mortality analyses relied on competing risks regression, after propensity score matching for patient and cancer characteristics. Results Compared with white patients, Asian intermediate- and high-risk external beam radiotherapy patients showed lower cancer-specific mortality (hazard ratio 0.58 and 0.70, respectively, both P ≤ 0.02). Additionally, Asian high-risk radical prostatectomy patients also showed lower cancer-specific mortality than white patients (hazard ratio 0.72, P = 0.04), but not Asian intermediate-risk radical prostatectomy patients (P = 0.08). Conversely, compared with white patients, African American intermediate-risk radical prostatectomy patients showed higher cancer-specific mortality (hazard ratio 1.36, P = 0.01), but not African American high-risk radical prostatectomy or intermediate- and high-risk external beam radiotherapy patients (all P ≥ 0.2). Finally, compared with white people, no cancer-specific mortality differences were recorded for Hispanic/Latino patients after external beam radiotherapy or radical prostatectomy, in both risk levels (P ≥ 0.2). Conclusions Relative to white patients, an important cancer-specific mortality advantage applies to intermediate-risk and high-risk Asian prostate cancer patients treated with external beam radiotherapy, and to high-risk Asian patients treated with radical prostatectomy. These observations should be considered in pretreatment risk stratification and decision-making. |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e80810efa11a598c123aa6e9b9a158 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....d4e80810efa11a598c123aa6e9b9a158 |
| قاعدة البيانات: |
OpenAIRE |