Hepatoregenerative role of bone morphogenetic protein-9
| العنوان: | Hepatoregenerative role of bone morphogenetic protein-9 |
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| المؤلفون: | Lucian Vukelic, Drazen Cuculic, Olga Cvijanović, Sanja Zoričić Cvek, Ivan Šoša, Tanja Ćelić, Zeljka Crncevic-Orlic, Alan Bosnar, Luka Dudaric, Dragica Bobinac |
| المصدر: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Medical science monitor Volume 17 Issue 12 |
| بيانات النشر: | International Scientific Information, Inc., 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | insulin, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, medicine.medical_specialty, animal structures, medicine.medical_treatment, GDF2, Carbohydrate metabolism, Biology, Models, Biological, Mice, Internal medicine, Growth Differentiation Factor 2, medicine, Animals, Humans, Insulin, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences, General Medicine, Transforming growth factor beta, Hypothesis, Liver regeneration, Liver Regeneration, bone morphogenetic protein-9, Endocrinology, GDF10, embryonic structures, biology.protein, GDF15, Signal transduction, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti, liver organization |
| الوصف: | Bone morphogenetic protein-9 (BMP-9) is a member of the transforming growth factor beta (TGF-β) super-family of cytokines, which regulate cell growth and differentiation during embryogenesis. Apart of that, the hypoglycemic potential of BMP-9 is of great interest. It has been confirmed that BMP-9, like insulin, improves glycemia in diabetic mice and regulates directional glucose metabolism in hepatocytes ; therefore it is proposed to be a candidate hepatic insulin-sensitizing substance (HISS). In liver fibrosis, due to the portocaval shunt, insulin bypasses the organ and the liver undergoes atrophy. Parenteral administration of insulin reverses atrophy by stimulating mitogenic activity of the hepatocytes. Because BMP-9 has a signaling pathway similar to other BMPs and insulin, it is to be expected that BMP-9 has a certain regenerative role in the liver. Also supporting the above-mentioned is evidence of BMP- 9 expression in Dissè's spaces and BMP-7’s mitogenic activity in mucosal cells. However, further studies are needed to confirm the possible regenerative role of BMP-9. |
| وصف الملف: | application/pdf |
| تدمد: | 1234-1010 |
| DOI: | 10.12659/msm.882108 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d494ef7fd80b11142ba66a94a1d36d https://doi.org/10.12659/msm.882108 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4d494ef7fd80b11142ba66a94a1d36d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12341010 |
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| DOI: | 10.12659/msm.882108 |