Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil
| العنوان: | Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil |
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| المؤلفون: | Paolla Ribeiro Gonçalves, Balduino Tschiedel, Fernanda G Penha, Adriana Costa e Forti, Reine Marie Fonseca, Alexis D Guedes, Flaviane A Prado, Rossana Santiago de Sousa Azulay, Suzana Lavigne, Rosangela Rea, Thais Della Manna, Milton César Foss, Marisa Helena César Coral, Luis Eduardo Calliari, Ana Cristina R. A. Faria, Alessandra S. M. Matheus, Karla Freire Rezende, Monica Tolentino, Maria de Fátima S Guedes, Maria do Carmo Arruda-Marques, Marcia Nery, Hermelinda Cordeiro Pedrosa, Marília B. Gomes, Pedro Carlos Barreto da Silva, Deborah Laredo Jezini, Antonio Carlos Pires, Melanie Rodacki, Renan Magalhães Montenegro Júnior, Roberta A Cobas, Naira Horta Melo, Renata Szundy Berardo, Alberto Ramos, Maria Cristina Foss-Freitas, Carlos Antonio Negrato, Leticia B Araujo, Janice Sepúlveda, Emerson Sampaio, João Regis Ivar Carneiro, Saulo C Silva, Sergio Atala Dib, Neuza Braga, Jorge Luiz Luescher, Nelson Rassi, João Soares Felício, Mirela Jobim de Azevedo, Cátia Cristina Silva Sousa Vergara Palma, Lucianne Righeti Monteiro Tannus, Ana Paula Dias Rangel Montenegro, Patricia Dualib, Odelissa S Matos, Luiz Antonio de Araujo, Daniela Aline Pereira, Fernando C Robles, Lenita Zajdenverg, Cristina Façanha, Alessandra T Zucatti, Roberta Salvodelli, Flávia Marques Santos, Luis Henrique Santos Canani, Renata Maria de Noronha |
| المصدر: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Diabetology & Metabolic Syndrome Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | endocrine system, Pediatrics, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, immune system diseases, Insulina, Diabetes mellitus, Internal Medicine, medicine, In patient, Type 1 diabetes, business.industry, Research, Insulin, nutritional and metabolic diseases, medicine.disease, Chronic complications, Diabetes mellitus tipo 1, Multicenter survey, TERAPÊUTICA MÉDICA, business, Brazil, Insulin regimens |
| الوصف: | Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D). Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups. Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). The majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001). Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits. |
| وصف الملف: | application/pdf |
| تدمد: | 1758-5996 |
| DOI: | 10.1186/1758-5996-6-67 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4be8cf3f23f83051e25b2c7d8b8ad1d https://doi.org/10.1186/1758-5996-6-67 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4be8cf3f23f83051e25b2c7d8b8ad1d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17585996 |
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| DOI: | 10.1186/1758-5996-6-67 |