The use of urea for the treatment of onychomycosis: a systematic review
| العنوان: | The use of urea for the treatment of onychomycosis: a systematic review |
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| المؤلفون: | Helen A. Banwell, Lisa Matricciani, Sindhrani Dars |
| المساهمون: | Dars, S, Banwell, HA, Matricciani, L |
| المصدر: | Journal of Foot and Ankle Research, Vol 12, Iss 1, Pp 1-11 (2019) Journal of Foot and Ankle Research |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Antifungal, medicine.medical_specialty, Antifungal Agents, lcsh:Diseases of the musculoskeletal system, medicine.drug_class, urea, Review, Administration, Cutaneous, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, systematic review, Fungal nail, Onychomycosis, onychomycosis, medicine, Humans, Urea, Orthopedics and Sports Medicine, Intensive care medicine, Adverse effect, fungal nail, 030203 arthritis & rheumatology, Evidence-Based Medicine, treatment, business.industry, Treatment options, Small sample, 030229 sport sciences, Topical urea, Treatment, Treatment Outcome, Systematic review, chemistry, Drug Therapy, Combination, lcsh:RC925-935, business, Prolonged treatment |
| الوصف: | Background Onychomycosis, a fungal infection affecting the nail plate, is a common condition often requiring prolonged treatment regimens, with low success rates. Urea is one treatment option, which is thought to improve the efficacy of topical and oral antifungal agents. Despite a theoretical basis for the use of urea for the treatment of onychomycosis, the evidence-base for this treatment has not been systematically reviewed. Aim The purpose of this study was to conduct a systematic literature review to determine the efficacy and safety of urea as a monotherapy and as adjunct therapy, compared to other treatment regimens for onychomycosis. Method A systematic literature search of ten electronic databases was conducted. Only studies that used microscopy and culture or other validated laboratory-based testing method to confirm the presence of a fungal infection before treatment were included. The outcome measures assessed were efficacy (defined in terms of mycological, clinical and complete cure) and safety (defined as self-reported adverse events). Results The systematic search yielded 560 unique studies for review. Of these, only six were eligible for inclusion. All studies were observed to have methodological concerns, most studies consisted of small sample sizes and were difficult to compare given heterogeneity in outcome measures and follow-up time. Despite this, a trend was observed to suggest that urea, when added to topical or oral antifungal treatment regimens, improved efficacy of the treatment. Conclusion This review suggests that topical urea, as an adjunct to topical and oral antifungal treatment regimens, may improve the efficacy of treatment. However, further research is needed. Electronic supplementary material The online version of this article (10.1186/s13047-019-0332-3) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1757-1146 |
| DOI: | 10.1186/s13047-019-0332-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d476ce3f082e4054ba68022c6e0be9f1 http://link.springer.com/article/10.1186/s13047-019-0332-3 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d476ce3f082e4054ba68022c6e0be9f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17571146 |
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| DOI: | 10.1186/s13047-019-0332-3 |