Premedication as primary prophylaxis does not influence the risk of acute infliximab infusion reactions in immune-mediated inflammatory diseases: A systematic review and meta-analysis
| العنوان: | Premedication as primary prophylaxis does not influence the risk of acute infliximab infusion reactions in immune-mediated inflammatory diseases: A systematic review and meta-analysis |
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| المؤلفون: | Jean Philippe Le Mouel, Marion Tilmant, Momar Diouf, Julien Loreau, Mathurin Fumery, Clara Yzet, Vincent Goëb, Siddarth Singh, Eric Nguyen-Khac, Jean-Louis Dupas, Justine Turpin, Franck Brazier |
| المساهمون: | CHU Amiens-Picardie, Department of Medicine, University of Washington [Seattle] |
| المصدر: | Digestive and Liver Disease Digestive and Liver Disease, WB Saunders, 2019, 51, pp.484-488. ⟨10.1016/j.dld.2018.12.002⟩ |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.drug_class, [SDV]Life Sciences [q-bio], Premedication, medicine.medical_treatment, Autoimmune Diseases, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Adrenal Cortex Hormones, law, Internal medicine, Humans, Medicine, Infusions, Intravenous, Randomized Controlled Trials as Topic, 030203 arthritis & rheumatology, Hepatology, business.industry, Gastroenterology, Inflammatory Bowel Diseases, medicine.disease, Infliximab, Injection Site Reaction, 3. Good health, Hypersensitivity reaction, Observational Studies as Topic, Meta-analysis, Histamine H1 Antagonists, Corticosteroid, 030211 gastroenterology & hepatology, Antihistamine, Immune-mediated inflammatory diseases, business, medicine.drug |
| الوصف: | Introduction Up to 25% of patients treated with infliximab experience hypersensitivity reactions. Prophylactic premedication prior to infliximab infusion, comprising corticosteroids and/or antihistamines, is widely used in clinical practice but its efficacy has recently been called into question due to the lack of pathophysiological rationale and validation by controlled trials. Materials and methods We conducted a comprehensive literature search of multiple electronic databases from inception to June 2017 to identify studies reporting the impact of corticosteroid and/or antihistamine premedication on the risk of acute ( Results Ten studies, eight observational studies and two randomized control trials, were identified including a total of 3892 patients with IMIDs, and 1,385 patients with IBD. Corticosteroid premedication was not associated with a decreased risk of hypersensitivity reaction in either IMIDs (7 studies; OR, 1.07, 95%CI, 0.64–1.78; I2 = 57.5%) or IBD (3 studies; OR, 1.04, 95% CI, 0.52–2.07; I2 = 57%). Antihistamine premedication was not associated with a decreased risk of hypersensitivity reaction in IMIDs (3 studies: OR, 1.39, 95% CI, 0.70–2.73; I2 = 85%). The combination of corticosteroids and antihistamines did not decrease the risk of acute infliximab infusion reaction in IMIDs (6 studies; OR, 2.12, 95% CI, 0.61–7.35; I2 = 94%), but was associated with an increased risk in IBD (4 studies, OR, 4.17, 95% CI, 1.61–10.78; I2 = 77%). Conclusion Corticosteroid and/or antihistamine premedication is not associated with a decreased risk of acute hypersensitivity reactions to infliximab in patients with IMIDs. We believe that these premedications should no longer be part of standard protocols. |
| تدمد: | 1590-8658 |
| DOI: | 10.1016/j.dld.2018.12.002 |
| DOI: | 10.1016/j.dld.2018.12.002⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43a0d446d79d15941cbe61720921b8c https://doi.org/10.1016/j.dld.2018.12.002 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d43a0d446d79d15941cbe61720921b8c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15908658 |
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| DOI: | 10.1016/j.dld.2018.12.002 |