Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract
| العنوان: | Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract |
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| المؤلفون: | Yuan-Chiang Chung, Yu-Ting Tsia, Chiu-Chen Huang, Jyh-Ching Chou, Yi-Hsien Lin, Jhih-Rou Su, Chih-Ping Hsu, Chih-Cheng Lin |
| المصدر: | Journal of Biomedicine and Biotechnology, Vol 2012 (2012) Journal of Biomedicine and Biotechnology |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cell cycle checkpoint, Article Subject, Colorectal cancer, Health, Toxicology and Mutagenesis, lcsh:Biotechnology, lcsh:Medicine, Antineoplastic Agents, Apoptosis, Biology, Litchi, Cell Line, Tumor, lcsh:TP248.13-248.65, Genetics, medicine, Humans, Molecular Biology, Cyclin, Dose-Response Relationship, Drug, Plant Extracts, Cell growth, lcsh:R, Cancer, food and beverages, Cell Cycle Checkpoints, General Medicine, Cell cycle, medicine.disease, Treatment Outcome, Cell culture, Seeds, Immunology, Cancer research, Molecular Medicine, Colorectal Neoplasms, Research Article, Biotechnology |
| الوصف: | The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins. Its pericarp has been shown to inhibit breast and liver cancer cell growth. However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported. In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined. The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells. LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity. This study providesin vitroevidence that LCSP serves as a potential chemopreventive agent for colorectal cancer. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1110-7251 1110-7243 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d435ecb87cd0d66fc59f7b4e27699368 https://doaj.org/article/0ada13c5420f4a41ad958ae32b4ae217 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d435ecb87cd0d66fc59f7b4e27699368 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11107251 11107243 |
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