Serum Carnitine Levels in Epileptic Children Before and During Treatment With Valproic Acid, Carbamazepine, and Phenobarbital
| العنوان: | Serum Carnitine Levels in Epileptic Children Before and During Treatment With Valproic Acid, Carbamazepine, and Phenobarbital |
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| المؤلفون: | M I Novo-Rodríguez, Santiago Rodríguez-Segade, Jesús Eirís-Puñal, Félix Camiña, Manuel Castro-Gago, José Couceiro |
| المصدر: | Journal of Child Neurology. 13:546-549 |
| بيانات النشر: | SAGE Publications, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | 0301 basic medicine, Drug, Adolescent, media_common.quotation_subject, Pharmacology, Statistics, Nonparametric, 03 medical and health sciences, 0302 clinical medicine, Carnitine, medicine, Animals, Humans, In patient, Child, media_common, Valproic Acid, Epilepsy, business.industry, Infant, Carbamazepine, Serum concentration, 030104 developmental biology, Child, Preschool, Phenobarbital, Pediatrics, Perinatology and Child Health, Anticonvulsants, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Serum levels of free, acyl, and total carnitine were determined in 32 patients with seizures, before and after 3, 6, and 12 months of treatment with valproic acid (17 patients), carbamazepine (10 patients), or phenobarbital (5 patients). In all three treated groups, both free and total carnitine levels showed a significant decline with respect to pretreatment levels. This decline was most marked and most consistent in patients treated with valproic acid. In 35% of the patients in this group, carnitine deficiency (ie, total camitine < 30 μmol/L) was observed by month 12. In none of the three groups were serum carnitine levels significantly correlated with the serum concentration of the drug. These findings suggest a need to monitor serum carnitine levels in children treated with any of these drugs. (J Child Neurol 1998;13:546-549). |
| تدمد: | 1708-8283 0883-0738 |
| DOI: | 10.1177/088307389801301104 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40c54a407f408ccce843ff398ab949c https://doi.org/10.1177/088307389801301104 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d40c54a407f408ccce843ff398ab949c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17088283 08830738 |
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| DOI: | 10.1177/088307389801301104 |