Varicella‐Zoster Virus–Specific Cellular Immunity in Subjects Given Acyclovir after Household Chickenpox Exposure
| العنوان: | Varicella‐Zoster Virus–Specific Cellular Immunity in Subjects Given Acyclovir after Household Chickenpox Exposure |
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| المؤلفون: | Hiroyuki Kojima, Shoki Yano, Hidetsugu Furukawa, Takuji Kumagai, Shunzo Chiba, Chiharu Igarashi, Makoto Kamada, Akiko Saito, Toyo Okui, Kenji Yuri |
| المصدر: | The Journal of Infectious Diseases. 180:834-837 |
| بيانات النشر: | Oxford University Press (OUP), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Herpesvirus 3, Human, Cellular immunity, Time Factors, viruses, Immunization, Secondary, Acyclovir, chemical and pharmacologic phenomena, Antibodies, Viral, medicine.disease_cause, Antiviral Agents, Herpesviridae, Virus, Chickenpox Vaccine, Chickenpox, medicine, Humans, Immunology and Allergy, Family, Aciclovir, Immunity, Cellular, integumentary system, business.industry, Varicella zoster virus, Infant, virus diseases, biochemical phenomena, metabolism, and nutrition, medicine.disease, Virology, Community-Acquired Infections, Infectious Diseases, Immunization, Child, Preschool, Antibody Formation, Immunology, Female, business, medicine.drug |
| الوصف: | The time course of primary cell-mediated immune responses to varicella-zoster virus (VZV) among persons receiving acyclovir prophylaxis after exposure to chickenpox has not been well defined. Fifteen children who had household exposure to varicella received prophylactic acyclovir (40 mg/kg/day for 7-14 days after exposure) and were studied for development of both antibody and cell-mediated immunity (CMI) to VZV. Twelve developed antibodies and/or CMI; 10 had no symptoms and 2 manifested mild varicella. Two were already immune to varicella and had booster immune responses. One was not infected and subsequently developed full-blown varicella. Although acyclovir given after exposure to VZV is highly effective and does not appear to attenuate the immune response, it remains necessary to confirm whether, in the absence of clinical varicella, persons acquire specific immunity. |
| تدمد: | 1537-6613 0022-1899 |
| DOI: | 10.1086/314950 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f1af3eed553fa1ddf11d6475311289 https://doi.org/10.1086/314950 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3f1af3eed553fa1ddf11d6475311289 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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| DOI: | 10.1086/314950 |