The 'Yin and Yang' of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
| العنوان: | The 'Yin and Yang' of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers |
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| المؤلفون: | Dietrich Büsselberg, Mariam Abotaleb, Ravinder Mamtani, Samson Mathews Samuel, Elizabeth Varghese, Sohaila Cheema |
| المصدر: | Cancers, Vol 10, Iss 10, p 346 (2018) Cancers |
| بيانات النشر: | MDPI AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Angiogenesis, Review, chemotherapy, lcsh:RC254-282, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, natural compounds, Medicine, anticancer therapy, Protein kinase B, PI3K/AKT/mTOR pathway, triple-negative breast cancers, business.industry, Wnt signaling pathway, apoptosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, signaling pathways, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, business, Deguelin, Fisetin |
| الوصف: | Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggressive, do not respond to conventional hormonal/human epidermal growth factor receptor 2 (HER2)-targeted interventions due to the lack of the respective receptor targets, have chances of early recurrence, metastasize, tend to be more invasive in nature, and develop drug resistance. The global burden of TNBCs is increasing regardless of the number of cytotoxic drugs being introduced into the market each year as they have only moderate efficacy and/or unforeseen side effects. Therefore, the demand for more efficient therapeutic interventions, with reduced side effects, for the treatment of TNBCs is rising. While some plant metabolites/derivatives actually induce the risk of cancers, many plant-derived active principles have gained attention as efficient anticancer agents against TNBCs, with fewer adverse side effects. Here we discuss the possible oncogenic molecular pathways in TNBCs and how the purified plant-derived natural compounds specifically target and modulate the genes and/or proteins involved in these aberrant pathways to exhibit their anticancer potential. We have linked the anticancer potential of plant-derived natural compounds (luteolin, chalcones, piperine, deguelin, quercetin, rutin, fisetin, curcumin, resveratrol, and others) to their ability to target multiple dysregulated signaling pathways (such as the Wnt/β-catenin, Notch, NF-κB, PI3K/Akt/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and Hedgehog) leading to suppression of cell growth, proliferation, migration, inflammation, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, and activation of apoptosis in TNBCs. Plant-derived compounds in combination with classical chemotherapeutic agents were more efficient in the treatment of TNBCs, possibly with lesser side effects. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bd4fad081a39e839754428292bfd93 http://www.mdpi.com/2072-6694/10/10/346 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3bd4fad081a39e839754428292bfd93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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