Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium
| العنوان: | Marijuana Smoking and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium |
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| المؤلفون: | Julien Berthiller, Joshua E. Muscat, Paul Brennan, Victor Wünsch Filho, Maria Paula Curado, Leticia Fernandez, Zuo-Feng Zhang, Erich M. Sturgis, Ana M. B. Menezes, Gilles Ferro, Elena Matos, Hal Morgenstern, Yuan Chin Amy Lee, Alexander W. Daudt, Sergio Koifman, Philip Lazarus, Sander Greenland, Paolo Boffetta, Mia Hashibe, José Eluf Neto, Stephen M. Schwartz, Chu Chen, Qingyi Wei |
| المساهمون: | Berthiller, J., Lee, Y.-C.A., Boffetta, P., Wei, Q., Sturgis, E.M., Greenland, S., Morgenstern, H., Zhang, Z.-F., Lazarus, P., Muscat, J., Chen, C., Schwartz, S.M., Neto, J.E., Wünsch Filho, V., Koifman, S., Curado, M.P., Matos, E., Fernandez, L., Menezes, A., Daudt, A.W., Ferro, G., Brennan, P., Hashibe, M. |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention. 18:1544-1551 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Epidemiology, Hashish, Article, Tobacco smoke, Interviews as Topic, Risk Factors, Environmental health, Humans, Medicine, Risk factor, Chi-Square Distribution, biology, business.industry, Smoking, Head and neck cancer, Case-control study, Odds ratio, Middle Aged, medicine.disease, biology.organism_classification, United States, Marijuana smoking, Surgery, Substance abuse, Latin America, Logistic Models, Oncology, Head and Neck Neoplasms, Case-Control Studies, Female, head and neck cancer, Cannabis, business, medicine.drug |
| الوصف: | Background: Marijuana contains carcinogens similar to tobacco smoke and has been suggested by relatively small studies to increase the risk of head and neck cancer (HNC). Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk. Methods: We pooled self-reported interview data on marijuana smoking and known HNC risk factors on 4,029 HNC cases and 5,015 controls from five case-control studies within the INHANCE Consortium. Subanalyses were conducted among never tobacco users (493 cases and 1,813 controls) and among individuals who did not consume alcohol or smoke tobacco (237 cases and 887 controls). Results: The risk of HNC was not elevated by ever marijuana smoking [odds ratio (OR), 0.88; 95% confidence intervals (95% CI), 0.67-1.16], and there was no increasing risk associated with increasing frequency, duration, or cumulative consumption of marijuana smoking. An increased risk of HNC associated with marijuana use was not detected among never tobacco users (OR, 0.93; 95% CI, 0.63-1.37; three studies) nor among individuals who did not drink alcohol and smoke tobacco (OR, 1.06; 95% CI, 0.47-2.38; two studies). Conclusion: Our results are consistent with the notion that infrequent marijuana smoking does not confer a risk of these malignancies. Nonetheless, because the prevalence of frequent marijuana smoking was low in most of the contributing studies, we could not rule out a moderately increased risk, particularly among subgroups without exposure to tobacco and alcohol. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1544–51) |
| وصف الملف: | STAMPA |
| تدمد: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-08-0845 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a73b4d585b39b3255d4eededb4aca2 https://doi.org/10.1158/1055-9965.epi-08-0845 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3a73b4d585b39b3255d4eededb4aca2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
|---|---|
| DOI: | 10.1158/1055-9965.epi-08-0845 |